Abstract: An information handling system presents audio information as audible sounds that include noise cancellation generated in response to environmental noise patterns detected by a microphone. For example, a machine learning model generates noise cancellation for plural environmental noise patterns, such as a baby crying, a dog barking, and a door bell ringing. The noise cancellation engine selectively applies and disables one or more types noise cancellation with the model based upon context at the information handling system, such as an application running on the system, a time of day or other factors.