Patents by Inventor GLEN GIESE

GLEN GIESE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSEMBLY OF BISPECIFIC ANTIBODIES
    Publication number: 20240101714
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Application
    Filed: June 15, 2023
    Publication date: March 28, 2024
    Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
  • Assembly of bispecific antibodies
    Patent number: 11725065
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: August 15, 2023
    Assignee: Genentech, Inc.
    Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
  • ASSEMBLY OF BISPECIFIC ANTIBODIES
    Publication number: 20200317820
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Application
    Filed: March 16, 2020
    Publication date: October 8, 2020
    Applicant: Genentech, Inc.
    Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
  • Assembly of bispecific antibodies
    Patent number: 10626189
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 21, 2020
    Assignee: Genentech, Inc.
    Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
  • ASSEMBLY OF BISPECIFIC ANTIBODIES
    Publication number: 20180162955
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Application
    Filed: October 20, 2017
    Publication date: June 14, 2018
    Applicant: Genentech, Inc.
    Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
  • Assembly of bispecific antibodies
    Patent number: 9862778
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: January 9, 2018
    Assignee: GENENTECH, INC.
    Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
  • ASSEMBLY OF BISPECIFIC ANTIBODIES
    Publication number: 20140336361
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Application
    Filed: April 11, 2014
    Publication date: November 13, 2014
    Applicant: GENENTECH, INC.
    Inventors: GLEN GIESE, AMY LIM, JOSEFINE PERSSON, JUSTIN SCHEER, AMBROSE WILLIAMS