Patents by Inventor Glen Kwon

Glen Kwon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210128736
    Abstract: The present technology relates generally to oligolactic acid conjugates and stereocomplexes of conjugates of gemcitabine and gemcitabine derivatives, micelle compositions containing such conjugates or stereocomplexes of conjugates, and methods of preparing and using such compositions to treat various cancers. The oligolactic acid conjugates and stereocomplexes of conjugates may include oligolactic acid comprising 2 to 20 lactic acid subunits and may be attached through an amide linkage to the nitrogen of the 4(N) of the gemcitabine or gemcitabine derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate or stereocomplex of conjugates may be readily prepared. Methods of inhibiting or killing cancer cells and treating gemcitabine sensitive cancers are also provided.
    Type: Application
    Filed: April 1, 2019
    Publication date: May 6, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Glen Kwon, Yu Tong Tam
  • Publication number: 20080038353
    Abstract: The present invention is in the field of polymer-based nano-carriers for the solubilization and delivery of hydrophobic drugs, and relates to methods of making said carriers, and to pharmaceutical compositions comprising said carriers. Novel PEO-b-PCL micelles and micelles containing cyclosporine A or analogs thereof are provided as well as a novel method for making said micelles that reduces aggregation and enhances delivery, the toxicity profile and biodistribution of hydrophobic drugs.
    Type: Application
    Filed: June 2, 2005
    Publication date: February 14, 2008
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Afsaneh Lavasanifar, Glen Kwon
  • Publication number: 20060251710
    Abstract: Hydrophobic drugs become more practical for treatments by being encapsulated in micelle compositions for increasing solubility. Micelle compositions may include an excipient tocopherol and/or prodrug formulations of the drug. Micelles extend the time period the drug remains in the micelles to improve drug circulation time and thereby drug delivery. Hydrophobic drugs for micelle encapsulation may include rapamycin, geldanamycin, and paclitaxel. Administration of these micelle compositions does not require Cremophor EL or Tween 80, avoiding serious side effects associated with these products which would previously accompany such drug administration.
    Type: Application
    Filed: April 12, 2006
    Publication date: November 9, 2006
    Inventors: Glen Kwon, Marcus Forrest
  • Patent number: 6168804
    Abstract: A method is provided for treating a Th1 mediated disease state by administration to a subject of a slow release vehicle such as a liposome or microsphere formulation containing an antigenic peptide and a Th1 specific immunomodulator wherein the antigenic peptide contains a T cell epitope and is released from the vehicle at a rate in the range from about 10 to 2 weight percent of the peptide in 24 hours at 37° C.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: January 2, 2001
    Assignee: University of Alberta
    Inventors: John Samuel, Glen Kwon