Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: A rupture apparatus (50) often deployed within a wall of a casing string (53) of an oil and gas well, comprising a housing (51) defining a housing bore (54) with a bore inlet and a bore outlet; a carriage carrying a rupturable component (12) the carriage being moveable in the housing bore between a rupturable position, an open and a closed position. Thus the bore can be opened or closed or closed subject to rupture of the rupturable component (12). Moreover, after rupture the bore can still be closed. Wireless signals are normally used to for control, especially electromagnetic or acoustic signals. A pressure balancing port (6) may be defined in a wall of the housing allowing fluid communication between at least a portion of the housing bore, and an outside of the housing which can pressure-balance the carriage such that it remains stationary unless actuated.

Abstract: A rupture apparatus (50) often deployed within a wall of a casing string (53) of an oil and gas well, comprising a housing (51) defining a housing bore (54) with a bore inlet and a bore outlet; a carriage carrying a rupturable component (12) the carriage being moveable in the housing bore between a rupturable position, an open and a closed position. Thus the bore can be opened or closed or closed subject to rupture of the rupturable component (12). Moreover, after rupture the bore can still be closed. Wireless signals are normally used to for control, especially electromagnetic or acoustic signals. A pressure balancing port (6) may be defined in a wall of the housing allowing fluid communication between at least a portion of the housing bore, and an outside of the housing which can pressure-balance the carriage such that it remains stationary unless actuated.

Abstract: A downhole flow control apparatus comprising: at least one tubular body locatable at a zone of a well, the tubular body having a longitudinal through bore and one or more transverse ports and a port covering device which, in use, is movable from a lower position in which the or each port is covered to an upper position in which the or each port is open; and at least one plugging device which is operable to travel downhole from the surface to locate within and seal the through bore of the tubular body, the plugging device including moving means to cause the port covering device to move from the lower position to the upper position thus allowing fluid communication between the through bore and the or each port.

Abstract: A fuel system includes a fuel injector having a fuel passage and a purging fluid passage formed therein. A nozzle tip inner surface defines a sac forming a blind end of the fuel passage in the fuel injector. A coaxial concentric check assembly includes a purging check movable to admit a purging fluid such as pressurized air into the fuel passage to purge the sac of fuel. Reduced injector dribble is observed from the purging of fuel.

Abstract: A fuel system includes a fuel injector having a fuel passage and a purging fluid passage formed therein. A nozzle tip inner surface defines a sac forming a blind end of the fuel passage in the fuel injector. A coaxial concentric check assembly includes a purging check movable to admit a purging fluid such as pressurized air into the fuel passage to purge the sac of fuel. Reduced injector dribble is observed from the purging of fuel.

Abstract: Operating a gaseous fuel engine includes injecting a pilot charge directly into a combustion chamber in an engine, and igniting one spray plume of the pilot charge. A flame front is propagated to other pilot spray plumes to produce an ignition flame for igniting later injected main charge spray plumes. Injection of the pilot and main charges is by way of the same fuel injection orifices.

Abstract: Apparatus and method for sealingly connecting tubular members in a wellbore. In a connector apparatus where a portion of a tubular member is radially expanded into sealing contact within a second tubular member, and the second tubular member has circumferential recesses on an inner surface, an annular resilient band member is arranged in the recesses. The annular resilient band member is acted on by the portion of the tubular member during expansion and maintains sealing contact to the portion after expansion.

Abstract: A morphable packer and method of setting the packer in a wellbore. The packer is a tubular member having a throughbore with a central portion having a greater diameter than each end portion with tapered portions there between. Gripping elements are arranged on the tapered portions. Morphing of the tubular member creates a seal between the central portion and an outer cylindrical structure, such as a wellbore or casing, and the gripping elements are moved radially outwards to engage with the cylindrical structure. The gripping elements act as slips which are activated by morphing the tubular member. Embodiments are described with the tubular member being a sleeve on a base pipe and, additionally, sealing and securing features in the form of elastomeric bands, lugs and wedges.

Abstract: A pipe coupling make up assembly and a method of making up a pipe coupling between tubular sections at a well. A first tubular section in a tubular string at the well is gripped and supported in the assembly. A second tubular is supported and moved to locate a first end of the second tubular section into an expanded first end of the first tubular section. A swaged die is arranged around the first tubular section and forced along the first tubular section towards the second tubular section. This causes the expanded first end to move radially inwards under elastic and plastic deformation and create a metal to metal seal between the first ends of the first and second tubular sections.

Abstract: Operating a gaseous fuel engine includes injecting a pilot charge directly into a combustion chamber in an engine, and igniting one spray plume of the pilot charge. A flame front is propagated to other pilot spray plumes to produce an ignition flame for igniting later injected main charge spray plumes. Injection of the pilot and main charges is by way of the same fuel injection orifices.

Abstract: An assembly having a sleeve member located over a tubular body, there being a chamber between the two and by increased pressure in the chamber the sleeve member is morphed to secure it to a well bore wall and create a seal between the sleeve and well bore wall to form an isolation barrier. The tubular body is formed in one or more sections so that annular planar faces are created for abutment between the sleeve member and the tubular body so as to remove the requirement for complex fittings and reduce the time of construction.

Abstract: Apparatus and method for sealingly connecting tubular members in a wellbore. In an arrangement where a portion of a tubular member is radially expanded into sealing contact within a second tubular member, and the second tubular member has circumferential recesses on an inner surface, a resilient member protrudes from a side wall of the recesses. The resilient member is acted on by the portion of the tubular member during expansion and maintains sealing contact to the portion after expansion.

Abstract: A ducted combustion system is disclosed. The ducted combustion system includes a combustion chamber bound by a flame deck surface of a cylinder head of an internal combustion engine and by a piston top surface of a piston disposed within the internal combustion engine. The system includes a fuel injector including a plurality of orifices, the plurality of orifices injecting fuel into the combustion chamber as a plurality of fuel jets. The system includes a duct structure defining a plurality of ducts and disposed within the combustion chamber between the flame deck surface and the piston top surface, the plurality of ducts being disposed such that each of the plurality of fuel jets at least partially enters one of the plurality of ducts upon being injected into the combustion chamber.

Abstract: A hydraulic fluid delivery tool for morphing a tubular downhole and a method of morphing a tubular downhole. The tool has spaced apart annular elastomer seal assemblies which operate by application of a piston against each elastomer to create a seal against the tubular. A first hydraulic fluid delivery line delivers fluid at a first pressure to operate the pistons. A second hydraulic fluid delivery line delivers fluid at a second pressure, lower than the first, to a location between the seals to morph the tubular and act on a second face of each piston to assist in maintaining the seal.

Abstract: A pipe coupling make up assembly and a method of making up a pipe coupling between tubular sections at a well. A first tubular section in a tubular string at the well is gripped and supported in the assembly. A second tubular is supported and moved to locate a first end of the second tubular section into an expanded first end of the first tubular section. A swaged die is arranged around the first tubular section and forced along the first tubular section towards the second tubular section. This causes the expanded first end to move radially inwards under elastic and plastic deformation and create a metal to metal seal between the first ends of the first and second tubular sections.

Abstract: A downhole flow control apparatus comprising: at least one tubular body locatable at a zone of a well, the tubular body having a longitudinal through bore and one or more transverse ports and a port covering device which, in use, is movable from a lower position in which the or each port is covered to an upper position in which the or each port is open; and at least one plugging device which is operable to travel downhole from the surface to locate within and seal the through bore of the tubular body, the plugging device including moving means to cause the port covering device to move from the lower position to the upper position thus allowing fluid communication between the through bore and the or each port.

Abstract: A downhole flow control apparatus comprising: at least one tubular body (1) locatable at a zone of a well, the tubular body (1) having a longitudinal through bore and one or more transverse ports (5a, 5b) and a port covering device (3) which, in use, is movable from a lower position in which the or each port is covered to an upper position in which the or each port is open; and at least one plugging device (6) which is operable to travel downhole from the surface to locate within and seal the through bore of the tubular body, the plugging device including moving means (10) to cause the port covering device (3) to move from the lower position to the upper position thus allowing fluid communication between the through bore and the or each port (5a, 5b).

Abstract: A ducted combustion system is disclosed. The ducted combustion system includes a combustion chamber bound by a flame deck surface of a cylinder head of an internal combustion engine and by a piston top surface of a piston disposed within the internal combustion engine. The system includes a fuel injector including one or more orifices, the one or more orifices injecting fuel into the combustion chamber as one or more fuel jets. The system includes one or more ducts disposed within the combustion chamber between the flame deck surface and the piston top surface, the one or more ducts being generally tubular shaped structures and being disposed such that each of the one or more fuel jets at least partially enters one of the one or more ducts upon being injected into the combustion chamber.

Abstract: A ducted combustion system is disclosed. The ducted combustion system includes a combustion chamber bound by a flame deck surface of a cylinder head of an internal combustion engine and by a piston top surface of a piston disposed within the internal combustion engine. The system includes a fuel injector including one or more orifices, the one or more orifices injecting fuel into the combustion chamber as one or more fuel jets. The system includes one or more ducts disposed within the combustion chamber between the flame deck surface and the piston top surface, the one or more ducts being generally tubular shaped structures and being disposed such that each of the one or more fuel jets at least partially enters one of the one or more ducts upon being injected into the combustion chamber.