Patents by Inventor Glen Michael FITZPATRICK

Glen Michael FITZPATRICK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250073271
    Abstract: Provided herein are compositions, and methods for administering a platelet derivative composition for reducing bleeding in a subject who is refractory to platelet transfusion. Methods herein can further include administering a platelet derivative composition to a subject having low platelet counts (e.g., having thrombocytopenia) and/or to maintain the number of platelets over a threshold amount, or to increase the number of platelets in the subject. Methods herein can include administering a therapeutic agent before and optionally after administering the platelet derivative composition to the subject. Methods herein can reduce or eliminate any dosing and/or scheduling adjustments of a therapeutic regimen due to a low platelet count.
    Type: Application
    Filed: November 15, 2024
    Publication date: March 6, 2025
    Applicant: Cellphire, Inc.
    Inventors: Keith Andrew MOSKOWITZ, Glen Michael FITZPATRICK
  • Publication number: 20250064856
    Abstract: Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject having Hermansky Pudlak Syndrome (HPS) or Bernard Soulier Syndrome (BSS), comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. The platelet derivatives can have numerous characteristics provided herein, that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors. Furthermore, provided herein are platelet derivatives, and methods using the same, that have numerous beneficial properties, as provided.
    Type: Application
    Filed: November 11, 2024
    Publication date: February 27, 2025
    Applicant: Cellphire, Inc.
    Inventors: Keith Andrew MOSKOWITZ, William Matthew DICKERSON, Maria Teresa ABREU-BLANCO, Lisa Ellen BOOTH, Emma Caitlin LESHAN, Glen Michael FITZPATRICK
  • Patent number: 12208122
    Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
    Type: Grant
    Filed: April 24, 2024
    Date of Patent: January 28, 2025
    Assignee: Cellphire, Inc
    Inventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
  • Publication number: 20240307453
    Abstract: Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject, comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. Such effective dose in illustrative embodiments, includes multiple individual doses, or a continuous dose administered within a time period, for example a time period of less than 4 hours. In certain aspects herein the subject is a subject having Hermansky Pudlak Syndrome (HPS). The platelet derivatives can have numerous characteristics provided herein that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors, and are HLA Class 1-characterized platelet derivatives (e.g., FDPDs), which in certain illustrative embodiments are HLA Class 1-matched FDPDs.
    Type: Application
    Filed: May 2, 2024
    Publication date: September 19, 2024
    Applicant: Cellphire, Inc.
    Inventors: Keith Andrew MOSKOWITZ, William Matthew DICKERSON, Maria Teresa ABREU-BLANCO, Lisa Ellen BOOTH, Emma Caitlin LESHAN, Ana Maria SWANSON, Arjun Shyam CHERUPALLA, Benjamin J. KUHN, William Allan ALEXANDER, Glen Michael FITZPATRICK
  • Publication number: 20240277771
    Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
    Type: Application
    Filed: April 24, 2024
    Publication date: August 22, 2024
    Applicant: Cellphire, Inc.
    Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Narendra Nath TANDON, Amber Nicole LEE, Glen Michael FITZPATRICK
  • Patent number: 11813572
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Grant
    Filed: January 20, 2023
    Date of Patent: November 14, 2023
    Assignee: Cellphire, Inc.
    Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
  • Publication number: 20230356150
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Application
    Filed: June 26, 2023
    Publication date: November 9, 2023
    Applicant: Cellphire, Inc.
    Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander Mathews
  • Publication number: 20230285465
    Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 14, 2023
    Applicant: Cellphire, Inc.
    Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Narendra Nath Tandon, Amber Nicole LEE, Glen Michael FITZPATRICK
  • Patent number: 11752468
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: September 12, 2023
    Assignee: Cellphire, Inc.
    Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
  • Publication number: 20230226493
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Application
    Filed: November 16, 2022
    Publication date: July 20, 2023
    Applicant: Cellphire, Inc.
    Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
  • Patent number: 11701388
    Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: July 18, 2023
    Assignee: Cellphire, Inc.
    Inventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
  • Publication number: 20230158455
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Application
    Filed: January 20, 2023
    Publication date: May 25, 2023
    Applicant: Cellphire, Inc.
    Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
  • Publication number: 20230149467
    Abstract: Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein.
    Type: Application
    Filed: November 4, 2022
    Publication date: May 18, 2023
    Applicant: Cellphire, Inc.
    Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
  • Patent number: 11529587
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: December 20, 2022
    Assignee: Cellphire, Inc.
    Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
  • Publication number: 20210368782
    Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Applicant: CELLPHIRE INC.
    Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
  • Publication number: 20200346167
    Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
  • Publication number: 20190008143
    Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.
    Type: Application
    Filed: January 10, 2017
    Publication date: January 10, 2019
    Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
  • Publication number: 20180169139
    Abstract: The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation. The composition is also suitable for treatment of organ conditions where blood flow is impaired or insufficient, resulting in organ distress, including tissue loss. The invention also relates to use as a prophylaxis to prevent medical consequences of anticipated conditions where depleted circulatory fluids, low blood pressure, or impaired organ perfusion require correction.
    Type: Application
    Filed: June 9, 2016
    Publication date: June 21, 2018
    Applicant: Cellphire, Inc.
    Inventors: Giora FEUERSTEIN, Glen Michael FITZPATRICK