Patents by Inventor Glen Michael FITZPATRICK
Glen Michael FITZPATRICK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250073271Abstract: Provided herein are compositions, and methods for administering a platelet derivative composition for reducing bleeding in a subject who is refractory to platelet transfusion. Methods herein can further include administering a platelet derivative composition to a subject having low platelet counts (e.g., having thrombocytopenia) and/or to maintain the number of platelets over a threshold amount, or to increase the number of platelets in the subject. Methods herein can include administering a therapeutic agent before and optionally after administering the platelet derivative composition to the subject. Methods herein can reduce or eliminate any dosing and/or scheduling adjustments of a therapeutic regimen due to a low platelet count.Type: ApplicationFiled: November 15, 2024Publication date: March 6, 2025Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Glen Michael FITZPATRICK
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Publication number: 20250064856Abstract: Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject having Hermansky Pudlak Syndrome (HPS) or Bernard Soulier Syndrome (BSS), comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. The platelet derivatives can have numerous characteristics provided herein, that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors. Furthermore, provided herein are platelet derivatives, and methods using the same, that have numerous beneficial properties, as provided.Type: ApplicationFiled: November 11, 2024Publication date: February 27, 2025Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, William Matthew DICKERSON, Maria Teresa ABREU-BLANCO, Lisa Ellen BOOTH, Emma Caitlin LESHAN, Glen Michael FITZPATRICK
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Patent number: 12208122Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: GrantFiled: April 24, 2024Date of Patent: January 28, 2025Assignee: Cellphire, IncInventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
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Publication number: 20240307453Abstract: Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject, comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. Such effective dose in illustrative embodiments, includes multiple individual doses, or a continuous dose administered within a time period, for example a time period of less than 4 hours. In certain aspects herein the subject is a subject having Hermansky Pudlak Syndrome (HPS). The platelet derivatives can have numerous characteristics provided herein that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors, and are HLA Class 1-characterized platelet derivatives (e.g., FDPDs), which in certain illustrative embodiments are HLA Class 1-matched FDPDs.Type: ApplicationFiled: May 2, 2024Publication date: September 19, 2024Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, William Matthew DICKERSON, Maria Teresa ABREU-BLANCO, Lisa Ellen BOOTH, Emma Caitlin LESHAN, Ana Maria SWANSON, Arjun Shyam CHERUPALLA, Benjamin J. KUHN, William Allan ALEXANDER, Glen Michael FITZPATRICK
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Publication number: 20240277771Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: ApplicationFiled: April 24, 2024Publication date: August 22, 2024Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Narendra Nath TANDON, Amber Nicole LEE, Glen Michael FITZPATRICK
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Patent number: 11813572Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: January 20, 2023Date of Patent: November 14, 2023Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20230356150Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: June 26, 2023Publication date: November 9, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander Mathews
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Publication number: 20230285465Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: ApplicationFiled: May 16, 2023Publication date: September 14, 2023Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Narendra Nath Tandon, Amber Nicole LEE, Glen Michael FITZPATRICK
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Patent number: 11752468Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: November 16, 2022Date of Patent: September 12, 2023Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20230226493Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: November 16, 2022Publication date: July 20, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Patent number: 11701388Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: GrantFiled: August 14, 2020Date of Patent: July 18, 2023Assignee: Cellphire, Inc.Inventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
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Publication number: 20230158455Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: January 20, 2023Publication date: May 25, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Publication number: 20230149467Abstract: Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein.Type: ApplicationFiled: November 4, 2022Publication date: May 18, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Patent number: 11529587Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: May 1, 2020Date of Patent: December 20, 2022Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20210368782Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.Type: ApplicationFiled: August 13, 2021Publication date: December 2, 2021Applicant: CELLPHIRE INC.Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
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Publication number: 20200346167Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: May 1, 2020Publication date: November 5, 2020Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20190008143Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.Type: ApplicationFiled: January 10, 2017Publication date: January 10, 2019Inventors: Joshua Dee, Anna Yu, Glen Michael Fitzpatrick, Richard O. Cliff
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Publication number: 20180169139Abstract: The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation. The composition is also suitable for treatment of organ conditions where blood flow is impaired or insufficient, resulting in organ distress, including tissue loss. The invention also relates to use as a prophylaxis to prevent medical consequences of anticipated conditions where depleted circulatory fluids, low blood pressure, or impaired organ perfusion require correction.Type: ApplicationFiled: June 9, 2016Publication date: June 21, 2018Applicant: Cellphire, Inc.Inventors: Giora FEUERSTEIN, Glen Michael FITZPATRICK