Patents by Inventor Glenn C. Telling

Glenn C. Telling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic Mice for Bioassay of Prions from Deer and Elk with Chronic Wasting Disease
    Publication number: 20090133133
    Abstract: The invention relates to the use of transgenic constructs to produce animal models for the study of chronic wasting disease.
    Type: Application
    Filed: October 14, 2008
    Publication date: May 21, 2009
    Applicant: University of Kentucky Research Foundation
    Inventor: Glenn C. Telling
  • Recombinant construct encoding epitope tagged PrP protein
    Patent number: 6602672
    Abstract: DNA constructs are provided of epitope-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chromatography such as epitope-tagged prion proteins (PrP). Transgenic animals expressing an epitope-tagged protein are provided, including transgenic animals expressing epitope-tagged PrP. Methods for distinguishing between the conformational shapes of a protein and a convenient method for isolating a tagged protein by immunoaffinity chromatographic methods are provided.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: August 5, 2003
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, Glenn C. Telling, Fred E. Cohen, Michael R. Scott
  • Transgenic animals expressing artificial epitope-tagged proteins
    Patent number: 6150583
    Abstract: DNA constructs are provided of epitope-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chromatography such as epitope-tagged prion proteins (PrP). Transgenic animals expressing an epitope-tagged protein are provided, including transgenic animals expressing epitope-tagged PrP. Methods for distinguishing between the conformational shapes of a protein and a convenient method for isolating a tagged protein by immunoaffinity chromatographic methods are provided.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: November 21, 2000
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, Glenn C. Telling, Fred E. Cohen, Michael R. Scott
  • Detecting cow, sheep and human prions in a sample and transgenic mice used for same
    Patent number: 6008435
    Abstract: Transgenic animals are produced which animals have (1) their endogenous PrP gene ablated; and (2) have an exogenous PrP gene from a genetically diverse animal. The transgenic animal is preferably a mouse, rat or hamster with mice being particularly preferred. The exogenous PrP gene is preferably from a sheep, cow, or pig with cow PrP genes being particularly preferred. When a mouse of the invention is inoculated with a sample containing prions which generally only infects a genetically diverse species (e.g. a cow) the mouse will become ill within about 250 days or less. Methods of producing the transgenic animals are disclosed including (1) microinjecting a mouse egg (having an ablated endogenous PrP gene) with a bovine PrP gene, or (2) breeding a mouse with an ablated PrP gene with a mouse with a bovine PrP gene. Mice produced are used to test samples for the presence of prions which generally only infect cows.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: December 28, 1999
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, Michael R. Scott, Glenn C. Telling
  • Detecting prions in a sample and prion preparation and transgenic animal used for same
    Patent number: 5792901
    Abstract: The invention includes an artificial PrP gene, a transgenic animal containing a PrP gene of another animal or the artificial PrP gene, a hybrid non-human mammal with an ablated endogenous prion protein gene and exogenous prion protein gene, assay methodology which uses the animals to detect pathogenic prions in a sample and standardized prion preparation used in the assay. The genome of a host animal (such as a mouse), is manipulated so that the animal is rendered susceptible to infection with prions which normally would infect only a genetically diverse test animal (such as human, cow or sheep). A PrP gene of the host is preferably manipulated to include a mutation which matches a mutation which causes prion disease in the genetically diverse mammal. Pathogenic prions in a sample can be detected by injecting the sample to be tested into a mammal of the invention which has been genetically manipulated so as to be susceptible to infection from prions in the sample.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: August 11, 1998
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, Michael R. Scott, Glenn C. Telling
  • Transgenic animals expressing artificial epitope-tagged proteins
    Patent number: 5789655
    Abstract: DNA constructs are provided of epitope-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chromatography such as epitope-tagged prion proteins (PrP). Transgenic animals expressing an epitope-tagged protein are provided, including transgenic animals expressing epitope-tagged PrP. Methods for distinguishing between the conformational shapes of a protein and a convenient method for isolating a tagged protein by immunoaffinity chromatographic methods are provided.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: August 4, 1998
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, Glenn C. Telling, Fred E. Cohen, Michael R. Scott