Patents by Inventor Glenn F. Spaulding

Glenn F. Spaulding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8891851
    Abstract: A home healthcare management system wherein a patient conducts self diagnoses and self testing, and manages their own medical records at home. A digital microscope is utilized as part of the system that is smaller, of lower cost, faster, of a higher dynamic range, and has a higher resolution than conventional microscopes. The microscope consists of an illumination source, a spatial sub-sampling device and a detector device. The digital microscope provides a vectored method of collecting images from a digital microscope that is independent of the optical resolution, and a slide based coordinate system, and a method of displaying images and communicating such images over the Internet in a file format that does not require a header or prior knowledge of magnification, coordinate system, or tiling structure. The system further includes an interface for physiological monitoring devices and a connection to the Internet for more comprehensive services.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: November 18, 2014
    Inventor: Glenn F. Spaulding
  • Publication number: 20110015494
    Abstract: A home healthcare management system wherein a patient conducts self diagnoses and self testing, and manages their own medical records at home. A digital microscope is utilized as part of the system that is smaller, of lower cost, faster, of a higher dynamic range, and has a higher resolution than conventional microscopes. The microscope consists of an illumination source, a spatial sub-sampling device and a detector device. The digital microscope provides a vectored method of collecting images from a digital microscope that is independent of the optical resolution, and a slide based coordinate system, and a method of displaying images and communicating such images over the Internet in a file format that does not require a header or prior knowledge of magnification, coordinate system, or tiling structure. The system further includes an interface for physiological monitoring devices and a connection to the Internet for more comprehensive services.
    Type: Application
    Filed: July 13, 2010
    Publication date: January 20, 2011
    Applicant: MICROSCOPES INTERNATIONAL, LLC
    Inventor: Glenn F. Spaulding
  • Patent number: 7355698
    Abstract: An imaging device and system for the high throughput imaging of multi-sample containers is described. Generally speaking, one or more containers capable of holding multiple sample volumes are fixed to a platform which is rotated during image acquisition operations. Images of sample volumes are obtained by moving an imaging device (e.g., a camera) from a first position to a second position across the one or more sample volumes. Because the platform is continuously rotated there is no lost time due to moving the samples (e.g., acceleration, deceleration and backlash compensation). Movement artifacts associated with motion of the imaging device occur in those times when the imaging device is “between” sample volumes, thereby eliminating any lost time due to this motion. Rather than, or in combination with, the aforementioned lights sources, additional light sources may be added to provide epi-illumination.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 8, 2008
    Assignee: Spin Diagnostics, Inc.
    Inventors: Shishir Shah, Glenn F. Spaulding
  • Publication number: 20030092058
    Abstract: A novel flow cytometer is described which includes a disposable sealed container that is rotated. Rotation the container directs cells to the inner surface of the container where they are analyzed, and sorted by photoactivated cross-linkers. The flow cytometer is simple, fast and safe.
    Type: Application
    Filed: April 15, 2000
    Publication date: May 15, 2003
    Inventor: GLENN F. SPAULDING
  • Publication number: 20030085523
    Abstract: A novel simple low cost paintball velocimeter is described. It is small, utilizing a light source and photodetection methods that can serve as a stand-alone velocimeter or integrated into the firing mechanism for greater control and accuracy. Additional features include an ability to collect, store and process data for graphical display and analysis.
    Type: Application
    Filed: July 25, 2002
    Publication date: May 8, 2003
    Inventors: Glenn F. Spaulding, Anthony Spaulding
  • Patent number: 6117674
    Abstract: A process for propagating a pathogen in a three-dimensional tissue mass cultured at microgravity conditions in a culture vessel containing culture media and a culture matrix is provided. The three-dimensional tissue mass is inoculated with a pathogen and pathogen replication in the cells of the tissue mass achieved.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: September 12, 2000
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Glenn F. Spaulding, David A. Wolf
  • Patent number: 6001643
    Abstract: A novel hydrodynamic cell culture environment is disclosed for a two-chamber roller bottle. The unstable hydrodynamics of a gas headspace media chamber is coupled through a center opening to a second zero headspace culture chamber. Coupling the two chambers creates novel fluid streamlines that add turbulence for improved mass transfer and slow media repletion. The exchange between chambers regulates turbulence and thus concomitant exchange of nutrients i.e., environmental control. It is disposable, automatable, and suited to culturing tissue for transplants.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: December 14, 1999
    Assignee: C-Med Inc.
    Inventor: Glenn F. Spaulding
  • Patent number: 5962324
    Abstract: A process for artificially producing three-dimensional optic tissue has been developed. The optic cells are cultured in a bioreactor at low shear conditions. The tissue forms as normal, functional tissue grows with tissue organization and extracellular matrix formation.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: October 5, 1999
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Adminstration
    Inventors: Kim C. O'Connor, Glenn F. Spaulding, Thomas J. Goodwin, Laurie A. Aten, Karen M. Francis, Delmar R. Caldwell, Tacey L. Prewett, Wendy S. Fitzgerald
  • Patent number: 5945338
    Abstract: A horizontally rotating cell culture system with enhanced oxygenation is described. The system achieves greater oxygenation through the use of a multiphase motor and non-linear acceleration/deceleration, to disrupt the establishment of boundary layers.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: August 31, 1999
    Assignee: VivoRx Pharmaceuticals
    Inventors: Glenn F. Spaulding, Mike Zerkus
  • Patent number: 5858783
    Abstract: Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under micro-gravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated micro-gravity created in a horizontal rotating wall culture vessel. The medium used for culturing the cells, especially a mixture of epithelial and mesenchymal cells contains a mixture of Mem-alpha and Leibovits L15 supplemented with glucose, galactose and fructose.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: January 12, 1999
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, David A. Wolf, Glenn F. Spaulding, Tacey L. Prewett
  • Patent number: 5851816
    Abstract: Artificial high-fidelity three-dimensional human urogenital tract carcinomas are propagated under in vitro-microgravity conditions from carcinoma cells. Artificial high-fidelity three-dimensional human urogenital tract carcinomas are also propagated from a coculture of normal urogenital tract cells inoculated with carcinoma cells. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: December 22, 1998
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Tacey L. Prewett, Glenn F. Spaulding, David A. Wolf
  • Patent number: 5660997
    Abstract: Substantially pure sex-associated membrane (SAM) proteins are used in methods to detect specific antibodies binding to X- or Y-SAM proteins.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Cytogam, Inc.
    Inventor: Glenn F. Spaulding
  • Patent number: 5648468
    Abstract: A method for Avian sex-preselection by identifying sex-specific proteins for maternal immunization to embryonic proteins is described. Sex-preselection proteins are used in sexing offsprings.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: July 15, 1997
    Inventor: Glenn F. Spaulding
  • Patent number: 5637477
    Abstract: A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virully infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: June 10, 1997
    Assignee: The United States of America as respresented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Glenn F. Spaulding, Thomas J. Goodwin, Kim C. O'Connor, Karen M. Francis, Angela D. Andrews, Tacey L. Prewett
  • Patent number: 5589112
    Abstract: An annular culture vessel for growing mammalian cells is constructed in a one piece integral and annular configuration with an open end which is closed by an endcap. The culture vessel is rotatable about a horizontal axis by use of conventional roller systems commonly used in culture laboratories. The end wall of the endcap has tapered access ports to frictionally and sealingly receive the ends of hypodermic syringes. The syringes permit the introduction of fresh nutrient and withdrawal of spent nutrients. The walls are made of conventional polymeric cell culture material and are subjected to neutron bombardment to form minute gas permeable perforations in the walls.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: December 31, 1996
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventor: Glenn F. Spaulding
  • Patent number: 5523228
    Abstract: A cell culture chamber with a novel hydrodynamic environment, constructed with gas permeable membranes is disclosed. The culture chamber is horizontally rotated, wall movement suspends cells and enhances oxygen mass transfer as cells aggregate and grow into 3-dimensional tissue.
    Type: Grant
    Filed: July 7, 1995
    Date of Patent: June 4, 1996
    Assignee: HMRI/CLMF
    Inventors: Marylou Ingram, Glenn F. Spaulding, James J. G. Craft, Chuen P. Ng, Ramez Saroufeem, Geza B. Techy, Ozkan Yazan
  • Patent number: 5496722
    Abstract: Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under microgravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: March 5, 1996
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, David A. Wolf, Glenn F. Spaulding, Tacey L. Prewett
  • Patent number: 5439362
    Abstract: A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing as sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: August 8, 1995
    Assignee: Cytogam, Inc.
    Inventor: Glenn F. Spaulding
  • Patent number: 5369012
    Abstract: A portion of an organic polymer article such as a membrane is made hydrophilic by exposing a hydrophobic surface of the article to a depth of about 50 to about 5000 angstroms to atomic oxygen or hydroxyl radicals at a temperature below 100.degree. C., preferably below 40.degree. C., to form a hydrophilic uniform surface layer of hydrophilic hydroxyl groups. The atomic oxygen and hydroxyl radicals are generated by a flowing afterglow microwave discharge, and the surface is outside of a plasma produced by the discharge. A membrane having both hydrophilic and hydrophobic surfaces can be used in an immunoassay by adhering antibodies to the hydrophobic surface. In another embodiment, the membrane is used in cell culturing where cells adhere to the hydrophilic surface. Prior to adhering cells, the hydrophilic surface may be grafted with a compatibilizing compound.
    Type: Grant
    Filed: March 26, 1992
    Date of Patent: November 29, 1994
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Steven L. Koontz, Glenn F. Spaulding
  • Patent number: 5346990
    Abstract: A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X-or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing as penn from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
    Type: Grant
    Filed: March 12, 1991
    Date of Patent: September 13, 1994
    Assignee: Cytogam, Inc.
    Inventor: Glenn F. Spaulding