Abstract: A method of handling defogging agents used in operating rooms. A defogging solution or agent is sterile filtered into an aerosol container that is ergonomically sized to fit the hand of the user. The solution is then capped with a sterile inert gas such as nitrogen as a propellant. The aerosol container is then placed in a pouch and sealed about its periphery. The sealed pouch is then sterilized by gamma radiation. Sterile wipes can also be included in the sterile pouch if desired so that they will be readily available to wipe foreign matter from instruments, masks, glasses and the like, prior to applying the defogging agent. In the operating room, the sterile pouch is opened and discarded and the sterile defogging agent is sprayed on sterile instruments, masks, glasses and other articles to prevent condensation from forming on surfaces due to temperature differential.