Abstract: Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.

Abstract: Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

Abstract: Tetrahydroprotoberbine (THPB) compounds and their use in the treatment of neurological, psychiatric and neurodegenerative diseases is provided. The compounds include d-govadine, l-govadine and racemic govadine, as well as d-THPBs of general formula (I). Enantioselective processes for preparing compounds of formula (I), and d- and l-govadine are also provided.

Abstract: The invention provides a side entry flow spool for use in production of oil and gas from a well. The side entry flow spool provides for a shift in the direction of flow of the hydrocarbons, from horizontal to vertical.

Abstract: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.

Abstract: This invention relates to mutagenized redox oxidase enzymes used to design enzyme electrodes with improved interference characteristics in the presence of mediator and oxygen in the assay. This recombinant modified enzyme has enhanced capability to transfer electrons to redox mediator instead of its natural electron acceptors such as O2, NAD, NADP, etc., which will improve the assay performance with less interference and higher sensitivity.

Abstract: Systems, methods and devices for trauma assessment and tourniquet, cricoids cartilage and tension pneumothorax training including use of modular arms, legs and torso parts, that each include self-contained simulators having realistic symptoms of bleeding, pulse rates, smells and the like so that students can be trained to both assess patient trauma and train students to control bleeding through tourniquets. Also the use of digital communication devices for presenting educational content and controlling the operations of the modular system parts for training purposes. Devices and methods of teaching cricothyrotomy techniques through reusable neck collars having segmented fluid filled chambers, adjustable trachea tools with moveable parts, as well as enhanced teaching and recording the teaching results from multiple students.

Abstract: A system and method for monitoring degradation of a device having a metal layer and a composite layer, such as a vehicle-mounted boom arm. The system can include a collar mounted on an outer surface of the device, a radiography device movably coupled to the collar, and a monitor. The radiography device can include a source of radiography signals positioned to direct radiography signals through at least a portion of the device and a detector to detect radiography signals that have passed through the device. The monitor can be connected to the detector to display an image of the device generated from the detected radiography signals. Anomalies in the device image can represent degradation in the device.

Abstract: An offshore oil production system, comprising a structure in a body of water, having a portion extending above a surface of the body of water; a first surface wellhead located at a top of the body of water; a second surface wellhead located at a top of the body of water; a first wellhead located at a bottom of the body of water; a second wellhead located at a bottom of the body of water; a first riser extending from the first wellhead to the first surface wellhead; and a second riser extending from the second wellhead to the second surface wellhead; wherein the first surface wellhead is a distance of less than about 12 feet from the second surface wellhead.

Abstract: Methods and devices for correcting sensing device signals, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of correcting a signal in a sensing device, comprising the steps of: providing a sensing device comprising a sensor, a first electrical pad, a second electrical pad, and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; determining a correction factor associated with the measured electrical property; and applying the correction factor to a signal generated by the sensor to produce a corrected signal.

Abstract: Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

Abstract: Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.

Abstract: Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.

Abstract: A subsea oil containment system, comprising a subsea collector located near a bottom of a body of water; a surface collector located near a surface of the body of water; and a riser connected to the subsea collector at a first end and extending to a second end located near the surface collector.

Abstract: A coupling assembly includes a fitting having a wall presenting an inner surface, surrounding a lumen, and an outer surface, opposing the inner surface. A barb extends radially away from the outer surface of the wall to a peak. A seal circumferentially surrounds the outer surface of the wall and is spaced from the peak of the barb. A hose presents an initial outer diameter. The hose extends over each of the seal and the barb such that the hose is deformed at the barb to present a displaced outer diameter that is greater than the initial outer diameter of the hose. A cage is spaced at least a distance from the peak of the barb and radially compresses the exterior surface of the hose and the seal to form an interference fit between each of the hose, the barb, and the cage.

Abstract: A machine for wrapping individual round crop bales with plastic film as they are rolled along the ground is disclosed having a frame, with an arm situated over the center of the bale, a rotating arm, attached to the end of the frame arm, a holder for the film roll attached to the rotating arm, allowing the roll to turn as the film feeds out, a roller mounted to the frame to push and roll the bale on the ground on its horizontal axis, as it is wrapped by the rotating arm, rotating on a vertical axis, resulting in a completely wrapped bale. In the preferred embodiment, the machine is mounted on the three point hitch of a tractor, with the rotating arm powered by the tractor hydraulics, and an optional “ground” roller mounted to the frame to support the wrapper close to the ground while wrapping.

Abstract: A system and method for monitoring degradation of a device having a metal layer and a composite layer, such as a vehicle-mounted boom arm. The system can include a collar mounted on an outer surface of the device, a radiography device movably coupled to the collar, and a monitor. The radiography device can include a source of radiography signals positioned to direct radiography signals through at least a portion of the device and a detector to detect radiography signals that have passed through the device. The monitor can be connected to the detector to display an image of the device generated from the detected radiography signals. Anomalies in the device image can represent degradation in the device.

Abstract: A coupling assembly includes a fitting having a wall presenting an inner surface, surrounding a lumen, and an outer surface, opposing the inner surface. A barb extends radially away from the outer surface of the wall to a peak. A seal circumferentially surrounds the outer surface of the wall and is spaced from the peak of the barb. A hose presents an initial outer diameter. The hose extends over each of the seal and the barb such that the hose is deformed at the barb to present a displaced outer diameter that is greater than the initial outer diameter of the hose. A cage is spaced at least a distance from the peak of the barb and radially compresses the exterior surface of the hose and the seal to form an interference fit between each of the hose, the barb, and the cage.