Patents by Inventor Glenn McGall

Glenn McGall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230092024
    Abstract: Disclosed herein is a substrate which includes a functional group protected with a photolabile group covalently attached to the substrate and a film of solvent thereof covering the substrate, where the thickness of the film is less than about 100 ?m. Also disclosed herein are methods of preparing such substrates. Further disclosed are methods of synthesizing polymers, methods of synthesizing arrays of polymers and methods of removing photolabile protecting groups. These methods all employ covering the substrate with a thin film of solvent where the thickness of the film is less than 100 ?m.
    Type: Application
    Filed: October 19, 2022
    Publication date: March 23, 2023
    Inventors: Glenn McGall, Paul Dentinger, Darren Crandall, Bolan Li
  • Patent number: 11180522
    Abstract: The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3?-OH group and a base that is attached to a label through a cleavable linker comprising a disulfide bond. In addition, both the disulfide bond and the cleavable chemical group are cleavable by a chemical reagent. Furthermore, after the disulfide bond is cleaved by the chemical reagent, there is no free thiol group linked to the base of the nucleotides according to the fragmentation reaction shown below as an example. Example compounds according to the present disclosure are shown as Formula (I): wherein w is 1-5; X is O, S, or BH3; B is a nucleotide base or an analog thereof, L1-3 are linkers; and D1 is a label.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: November 23, 2021
    Assignee: Centrillion Technology Holdings Corporation
    Inventors: Moti Jain, Kendall Hoff, Glenn McGall, Wei Zhou
  • Patent number: 11149301
    Abstract: The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of poly(methylsilsesquioxane)-bonded polymers as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 19, 2021
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventor: Glenn McGall
  • Patent number: 11060139
    Abstract: Provided herein are methods and compositions for the sequencing of long nucleic acids, such as DNA. The methods and compositions are suited for the spatial labeling and sequencing of long nucleic acid molecules.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: July 13, 2021
    Assignee: Centrillion Technology Holdings Corporation
    Inventors: Glenn McGall, Justin Costa, Wei Zhou
  • Patent number: 10913070
    Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: February 9, 2021
    Assignee: Centrillion Technologies Taiwan Co. LTD.
    Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall
  • Publication number: 20210032776
    Abstract: The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3?-bound to a substrate to 5?-bound to another substrate. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array. These processes can preserve the original patterns of the synthesized oligonucleotide after the inversion. These process can be achieved via the formation of a hydrogel layer in-between a donor substrate and an acceptor substrate through a polymerization reaction forming the hydrogel layer.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 4, 2021
    Inventors: Paul DENTINGER, Justin COSTA, Glenn MCGALL, Filip CRNOGORAC, Wei ZHOU
  • Publication number: 20200384436
    Abstract: The present disclosure provides methods and processes for forming a pattern of oligonucleotides on a microarray. A method for forming a pattern of oligonucleotides on a microarray may include forming a photoresist layer by applying a photoresist composition onto an underlying layer of a substrate, exposing a dose of light through a patterned mask onto the substrate, and removing protective groups on a section of the plurality of functional groups within at least one exposed region of the substrate, wherein the photoresist composition comprises a photoacid generator, an acid scavenger and a photosensitizer, wherein the underlying layer comprises a plurality of functional groups protected by protective groups; thereby forming a pattern on the substrate, wherein the pattern comprises the at least one exposed region, and wherein the at least one exposed region is no more than 1 micrometer in at least one dimension.
    Type: Application
    Filed: January 5, 2019
    Publication date: December 10, 2020
    Inventors: Filip CRNOGORAC, Glenn MCGALL, Paul DENTINGER, T. Scott POLLOM, Wei ZHOU
  • Publication number: 20200362397
    Abstract: The present disclosure provides methods, device, and system for a hybridization assay to detect nucleic acid targets. The assay may use a probe array format with addressable microwells. Each microwell may retain a plurality of copies of one probe which may be complementary to a portion of a specific nucleic acid target. The plurality of copies of probes may be produced from a pooled library of probe sequences by amplification techniques, including, rolling circle amplification and emulsion-PCR. Detection of hybridization may rely on methods using ion-sensitive field effect transistor (ISFET) and optical detectors to detect signals indicating the presence of the nucleic acid targets.
    Type: Application
    Filed: May 31, 2018
    Publication date: November 19, 2020
    Inventors: Wei ZHOU, Glenn MCGALL, Rui MEI, Filip CRNOGORAC
  • Patent number: 10695735
    Abstract: The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3?-bound to 5?-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: June 30, 2020
    Assignee: Centrillion Technology Holdings Corporation
    Inventors: Wei Zhou, Glenn McGall, Vijay Singh
  • Patent number: 10597715
    Abstract: Provided herein are methods and compositions for the sequencing of long nucleic acids, such as DNA. The methods and compositions are suited for the spatial labeling and sequencing of long nucleic acid molecules.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 24, 2020
    Assignee: Centrillion Technology Holdings
    Inventors: Wei Zhou, Filip Crnogorac, Glenn McGall, Jian Cao
  • Publication number: 20200070119
    Abstract: The present disclosure provides methods, device, and system for wafer processing. The wafer processing apparatus uses a nozzle in a lid to disperse a solution to the surface of a wafer. Further, the wafer is positioned on top of a vacuum chuck and does not spin while the solution is dispensed over the surface of the wafer via surface tension, thereby permitting the first solution to react with a reagent on the surface. Further, when dispensing the first solution, a separation gap between the lid and the wafer is at a predetermined distance, for example, from about 20 ?m to about 2 mm.
    Type: Application
    Filed: May 23, 2018
    Publication date: March 5, 2020
    Inventors: Filip CRNOGORAC, Glenn McGALL, Bolan LI, Wei ZHOU
  • Publication number: 20200071752
    Abstract: The present disclosure relates to processes for derivatizing a reactive pentafluorophenyl surface of a substrate with a covalently bonded thin film of poly(methylsilester sesquioxane)-bonded polymers as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
    Type: Application
    Filed: March 6, 2018
    Publication date: March 5, 2020
    Inventor: Glenn McGALL
  • Publication number: 20200047146
    Abstract: The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of hydroxalkylated poly(acrylamide) as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.
    Type: Application
    Filed: March 6, 2018
    Publication date: February 13, 2020
    Inventor: Glenn MCGALL
  • Publication number: 20200038831
    Abstract: Provided herein are methods and compositions for the fabrication of patterned arrays, such as nucleotide arrays. The methods and compositions are suited for the transfer and reorientation of array components.
    Type: Application
    Filed: July 2, 2019
    Publication date: February 6, 2020
    Inventors: Wei ZHOU, Filip CRNOGORAC, Glenn MCGALL, Jian CAO
  • Patent number: 10533216
    Abstract: The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3?-bound to 5?-bound. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: January 14, 2020
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventors: Glenn McGall, Vijay Singh
  • Publication number: 20190366292
    Abstract: Disclosed herein is a substrate which includes a functional group protected with a photolabile group covalently attached to the substrate and a film of solvent thereof covering the substrate, where the thickness of the film is less than about 100 ?m. Also disclosed herein are methods of preparing such substrates. Further disclosed are methods of synthesizing polymers, methods of synthesizing arrays of polymers and methods of removing photolabile protecting groups. These methods all employ covering the substrate with a thin film of solvent where the thickness of the film is less than 100 ?m.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Inventors: Glenn McGall, Darren Crandall, Bolan Li, Paul Dentinger
  • Patent number: 10391467
    Abstract: Provided herein are methods and compositions for the fabrication of patterned arrays, such as nucleotide arrays. The methods and compositions are suited for the transfer and reorientation of array components.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 27, 2019
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventors: Wei Zhou, Filip Crnogorac, Glenn McGall, Jian Cao
  • Patent number: 10385335
    Abstract: Provided herein are methods and compositions for coating surfaces with polymers. The methods and compositions are suited for conducting biological reactions.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 20, 2019
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventor: Glenn McGall
  • Patent number: 10307724
    Abstract: The present disclosure provides methods, device, and system for wafer processing. The wafer processing apparatus uses lid dispenser to disperse at least one reagent to the surface of the wafer. Further, the wafer is positioned on top of a rotatable vacuum chuck configured to spread at least one reagent over the surface of the wafer via a centrifugal force or surface tension, thereby permitting the at least one reagent to react with an additional reagent. Further, when dispensing the at least one reagent, a separation gap between the lid dispenser and the wafer is at a predetermined distance, for example, from 50 ?m to 2 mm.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: June 4, 2019
    Assignee: CENTRILLION TECHNOLOGY HOLDINGS CORPORATION
    Inventors: Filip Crnogorac, Glenn McGall, Bolan Li
  • Publication number: 20180345290
    Abstract: A microarray carrier assembly including a scan tray and a plurality of microarray blocks detachably disposed on the scan tray is provided. The scan tray includes a frame including an opening and a slot, and a transparent substrate covering the opening of the frame. Each of the microarray blocks includes a main body, a probe array distributed on the main body and facing towards the transparent substrate of the scan tray, and a plurality of guiding pins disposed on the main body and surrounding the probe array, wherein a top surface area of the guiding pin opposite to the main body is less than a bottom surface area of the guiding pin connected to the main body, and the guiding pins are detachably inserted into the slot of the frame of the scan tray.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Applicant: Centrillion Technologies Taiwan Co. LTD.
    Inventors: Wei Zhou, Lin-Hsin Tu, Yao-Kuang Chung, Tzu-Kun Ku, Glenn McGall