Abstract: A novel anhydrous crystalline polymorph of 1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine monohydrochloride is disclosed, together with pharmaceutical formulations containing the compound. The novel polymorph exhibits a diminished food effect when administered to human subjects.

Abstract: A system for delivering an active substance has sustained release of the active substance in the intestinal tract. This delivery system is especially useful for an active substance such as a .beta.-lactam antibiotic which preferably has minimal exposure to the acidic environment of the stomach. Particles comprise an active ingredient disposed in a core which has at least one coating of a prolamine and one coating of an enteric compound thereon. The particles may be very small and suspended in a liquid medium.

Abstract: A non-invasive nuclear device for communicating pressure inside a body to the exterior, such as from within the cranium, bladder or vena cava, of an animal or human, the device including a housing having an interior communicating through a conduit of deformable metallic material with a fluid pressure sensing device positioned within the body portion being monitored, the housing being mounted on the body adjacent the body portion being monitored, a shaped mass of radioactive material together with radiation shield means being disposed within the housing interior together with urging means for producing a predetermined shielding relationship between the radioactive mass and the shield means, the radioactive mass being supported on the urging means for guide movement relative to the shield means and the sensed pressure being exerted through a pressure transmitting fluid flowing within the deformable metal conduit against the urging means for modifying the shielding relationship between the radioactive mass and t

Abstract: A pressure sensor apparatus primarily for sensing pressure in a body cavity such as the cranium, bladder or vena cava of an animal or human comprising a housing having a diaphragm dividing the interior of the housing into two chambers. A member containing filter material is connected to the housing and communicates with one of the chambers formed in the housing. The other chamber contains radioactive fluid and is connected to a variable volume chamber that receives a volume of radioactive fluid which is proportional to the pressure sensed by the flexible member. A radiation detector senses the volume of radioactive fluid in the variable volume chamber.