Abstract: Systems, including methods and apparatus, for particle manipulation to perform assays.

Abstract: Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates.

Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

Abstract: Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates.

Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.

Abstract: Devices for automatically feeding sample containers into and out of an analyzer. The device may include (1) a first station that receives and initiates transport of a sample container into an analyzer for analysis, (2) a second station where the sample container is handed off to a transporter that carries the sample container to and from an examination site inside the analyzer, and (3) a third station that collects the sample container after examination. The device also may include a singulation mechanism configured to separate a sample container from a stack of sample containers, and/or a stacking mechanism configured to add a sample container to a stack of sample containers. The singulation and stacking mechanisms may include lifter and latch components.

Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.

Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.

Abstract: Devices and methods for supporting a sample container. In one embodiment, the device includes a holder for supporting a sample container, and a releasable clamp mechanism that applies a force against a side of the sample container. In another embodiment, the device includes a holder for supporting a sample container, wherein the holder has a central opening that permits analysis of a sample to be carried out from below the holder, and an open end that permits a sample container transfer device to enter a portion of the holder. In yet another embodiment, the device includes a holder for supporting a sample container, and drive mechanisms that move the holder between a docking station outside an analyzer and an examination site inside the analyzer, so that the holder can function both as a sample delivery device in and out of the analyzer, and as a moveable stage for supporting the sample container at the examination site.

Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.

Abstract: Devices and methods for supporting a sample container. In one embodiment, the device includes a holder for supporting a sample container, and a releasable clamp mechanism that applies a force against a side of the sample container. In another embodiment, the device includes a holder for supporting a sample container, wherein the holder has a central opening that permits analysis of a sample to be carried out from below the holder, and an open end that permits a sample container transfer device to enter a portion of the holder. In yet another embodiment, the device includes a holder for supporting a sample container, and drive mechanisms that move the holder between a docking station outside an analyzer and an examination site inside the analyzer, so that the holder can function both as a sample delivery device in and out of the analyzer, and as a moveable stage for supporting the sample container at the examination site.

Abstract: A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths permit top/bottom illumination and/or top/bottom detection, or combinations thereof.

Abstract: A high-throughput light detection instrument and method are described. Confocal optics structure enables exclusive light detection from a sensed volume in a composition.

Abstract: Devices and methods for transmitting light through an aperture in a surface substantially without leakage. In one embodiment, the device comprises an optical relay structure having an end configured to transmit light, and an opaque collar positioned around the end and configured to reorient to conform to the surface when the end and the aperture are aligned. In another embodiment, the device comprises an optical relay structure having an end configured to transmit light, and an opaque collar positioned around the end and spring-biased relative to the end, so that the opaque collar is forced against the surface when the end and the aperture are aligned. The devices further may include a stop mechanism for limiting movement of the opaque collar, a registration mechanism for aligning the end and the aperture, and a light source and/or a detector for generating or detecting light, among others.

Abstract: A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.

Abstract: A method of electronically aligning a first sensor having two substantially nonparallel sense axes producing first and second output signals and carried by a garment so as to be positioned proximate to a joint's first axis of movement with a second sensor having two substantially nonparallel sense axes producing third and fourth output signals and carried by the garment so as to be positioned proximate to the joint's second axis of movement, comprises the steps of: reading values for the third and fourth output signals at two points while the joint is moved substantially along only the joint's first axis; electronically combining the third and fourth signals so that the combined output is constant; reading values for the first and second output signals at two points while the joint is being moved substantially along only the joint's second axis; and electronically combining the first and second signals so that the combined output is constant.

Abstract: A man-machine interface comprises a sensor having first and second ends. The sensor carriers four transducers oriented therearound such that the sensor is responsive to flex in two directions. An affixing mechanism, such as a glove or cloth strap, is provided for affixing the man-machine interface to a patient's body. A first mounting mechanism is provided for rigidly mounting the first end of the sensor to the affixing mechanism. A second mounting mechanism is provided for slidably mounting a second end of the sensor to the affixing mechanism. In that manner, flex in two directions can be sensed without adding any tensile forces to the sensor as a result of the joint being flexed.