Patents by Inventor Glenn R. Larsen

Glenn R. Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for Modulating TRPV3 Function
    Publication number: 20100152209
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: November 3, 2006
    Publication date: June 17, 2010
    Applicant: Hydra Biosciences Inc.
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, JR., Anu Mahadevan, Peter Meltzer, Magdalene M. Moran, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen
  • P-selectin ligand protein
    Patent number: 7563760
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: July 21, 2009
    Assignee: Genetics Institute, LLC
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • METHODS AND COMPOSITIONS FOR TREATING DISORDERS
    Publication number: 20090143377
    Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.
    Type: Application
    Filed: June 23, 2008
    Publication date: June 4, 2009
    Inventors: Howard Ng, Manfred Weigele, Magdalene Moran, Jayhong Chong, Christopher Fanger, Glenn R. Larsen, Donato Del Camino, Neil Hayward, Steven P. Adams, Amy Ripka
  • NOVEL P-SELECTIN LIGAND PROTEIN
    Publication number: 20090104180
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Application
    Filed: July 3, 2008
    Publication date: April 23, 2009
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Novel P-selectin Ligand Protein
    Publication number: 20090028883
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 29, 2009
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Compounds for modulating TRPV3 function
    Publication number: 20090018147
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: May 12, 2008
    Publication date: January 15, 2009
    Applicant: Hydra Biosciences Inc.
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, Magdalene M. Moran, Howard Ng, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen
  • Novel P-Selectin Ligand Protein
    Publication number: 20080280327
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Application
    Filed: July 3, 2008
    Publication date: November 13, 2008
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Compounds for modulating TRPV3 function
    Publication number: 20080146611
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: September 14, 2007
    Publication date: June 19, 2008
    Applicant: Hydra Biosciences Inc.
    Inventors: Magdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
  • Novel P-selectin ligand protein
    Publication number: 20030018181
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Application
    Filed: August 21, 2001
    Publication date: January 23, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Fusions of P-selectin ligand protein and polynucleotides encoding same
    Patent number: 6277975
    Abstract: Fusions proteins comprising P-selectin ligand proteins are disclosed, including fusions with immunoglobulins, BMPs, AGP and IL-11. Polynucleotides encoding such fusions are also disclosed.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: August 21, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Nucleic acid encoding a novel P-selectin ligand protein
    Patent number: 5843707
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Method of inhibiting P-selectin ligand activity
    Patent number: 5840679
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw, Ray Camphausen
  • Thrombolytic proteins
    Patent number: 5837518
    Abstract: Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: November 17, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Tim J. Ahern
  • P-selectin ligand protein
    Patent number: 5827817
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 27, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw, Ray Camphausen
  • Deletion and glycosylation mutant of human tissue plasminogen activator
    Patent number: 5258298
    Abstract: Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: November 2, 1993
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Tim J. Ahern
  • DNA sequences encoding novel thrombolytic proteins
    Patent number: 5071972
    Abstract: Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.
    Type: Grant
    Filed: October 19, 1988
    Date of Patent: December 10, 1991
    Assignee: Genetics Institute, Inc.
    Inventor: Glenn R. Larsen
  • Truncated thrombolytic proteins
    Patent number: 5002887
    Abstract: Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by the presence of 0, 1, 2 or 3 N-linked polysaccharide substituents covalently bonded thereto and by a polypeptide sequence of the formula(a)A-R.sup.1 -B-R.sup.2 -C-R.sup.3 Dwherein A, B, C, and D are the following polypeptide sequences substantially as shown in FIG. 1:A is Gly-.sub.3 or Ser.sub.1 through Trp.sub.116, encompassing domain a;B is Ala.sub.120 through Gly.sub.183 ;C is Ala.sub.187 through Leu.sub.447 ;D is Val.sub.451 through Pro.sub.527 ; anda is a peptide domain comprising a sequence of 0-93 amino acids selected from the sequence Gly.sub.-3 or Ser.sub.1 through Thr.sub.91 ; R.sup.1, R.sup.2 and R.sup.3 are each a tripeptide sequence linking said A, B, C and D by peptide bonds, up to three of R.sup.1, R.sup.2 and R.sup.3 being a tripeptide sequence other than Asn-X-Thr or Asn-X-Ser, wherein X is any amino acid.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: March 26, 1991
    Assignee: Genetics Institute, Inc.
    Inventor: Glenn R. Larsen