Patents by Inventor Glenn T. Syftestad

Glenn T. Syftestad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery system for controlled release of bioactive factors
    Patent number: 5629009
    Abstract: A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: May 13, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: Cato T. Laurencin, Paul A. Lucas, Glenn T. Syftestad, Abraham Domb, Julie Glowacki, Robert S. Langer
  • Delivery system for controlled release of bioactive factors
    Patent number: 5545409
    Abstract: A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
    Type: Grant
    Filed: April 5, 1994
    Date of Patent: August 13, 1996
    Assignee: Massachusetts Institute of Technology
    Inventors: Cato T. Laurencin, Paul A. Lucas, Glenn T. Syftestad, Abraham Domb, Julianne Glowacki, Robert S. Langer
  • Delivery system for controlled release of bioactive factors
    Patent number: 5356630
    Abstract: A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
    Type: Grant
    Filed: May 7, 1993
    Date of Patent: October 18, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: Cato T. Laurencin, Paul A. Lucas, Glenn T. Syftestad, Abraham Domb, Julianne Glowacki, Robert S. Langer
  • Process of adapting soluble bone protein for use in stimulating osteoinduction
    Patent number: 4620327
    Abstract: A method for treating implants such as biodegradable masses, xenogenic bony implants, allografts and prosthetic devices with soluble bone protein to enhance or stimulate new cartilage and/or bone formation. Substrate immobilization or surface coating techniques retard diffusion of the soluble bone protein away from the implant site so that cartilage and bone growth is initiated.
    Type: Grant
    Filed: July 5, 1984
    Date of Patent: November 4, 1986
    Inventors: Arnold I. Caplan, Glenn T. Syftestad
  • Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
    Patent number: 4609551
    Abstract: A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: September 2, 1986
    Inventors: Arnold Caplan, Glenn T. Syftestad
  • Bone protein purification process
    Patent number: 4608199
    Abstract: A process of extracting and purifying a bone protein capable of stimulating chondrogenic expression in undifferentiated cells in culture. The purification process is monitored at various stages by bioassaying the bone protein for chondrogenic activity in embryonic limb bud mesenchymal cell cultures.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: August 26, 1986
    Inventors: Arnold Caplan, Glenn T. Syftestad