Patents by Inventor Glenville Jones

Glenville Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 24-sulfur-substituted analogs of 1alpha, 25-dihydroxy vitamin D3
    Publication number: 20030149005
    Abstract: The present invention provides novel C24-aryl sulfone analogs of 1&agr;,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1&agr;,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
    Type: Application
    Filed: August 22, 2002
    Publication date: August 7, 2003
    Inventors: Gary H. Posner, Kenneth R. Crawford, Hong Woon Yang, Jay A. White, Glenville Jones, Byung-Chul Suh, HeungBae Jeon, Mark Hatcher
  • Retinoid metabolizing protein
    Patent number: 6306624
    Abstract: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: October 23, 2001
    Assignee: Queen's University at Kingston
    Inventors: P. Martin Petkovich, Jay A. White, Barbara R. Beckett, Glenville Jones
  • Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2
    Patent number: 6251883
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 26, 2001
    Assignee: Bone Care International, Inc.
    Inventors: Ronald L. Horst, Charles W. Bishop, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1&agr;,24 (S)-dihydroxy vitamin D2
    Patent number: 6211168
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 3, 2001
    Assignees: Bone Care International, Inc, The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1.alpha.,24(S)-Dihydroxy vitamin . D.sub2
    Patent number: 6166000
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 26, 2000
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Glenville Jones, Joyce C. Knutson, Stephen Strugnell
  • Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vitamin D2
    Patent number: 6143910
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: November 7, 2000
    Assignees: Bone Care International, Inc., The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Retinoid metabolizing protein
    Patent number: 6063606
    Abstract: Amino acid sequences and corresponding nucelic acid sequence of retinoid metabolizing protein found in zebrafish and human are described.
    Type: Grant
    Filed: October 1, 1996
    Date of Patent: May 16, 2000
    Inventors: P. Martin Petkovich, Jay A. White, Barbara R. Beckett, Glenville Jones
  • Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
    Patent number: 5789397
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Glenville Jones, Ronald L. Horst, Nicholas J. Koszewski, Joyce C. Knutson, Raju Penmasta, Robert M. Moriarty, Stephen Strugnell, Timothy A. Reinhardt, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2
    Patent number: 5786348
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao