Patents by Inventor Gloria C. Paschal

Gloria C. Paschal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vindesine synthesis
    Patent number: 4210584
    Abstract: Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: July 1, 1980
    Assignee: Eli Lilly and Company
    Inventors: Gloria C. Paschal, Gerald L. Thompson
  • Process of producing 5'-hydroxyleurosine and related compounds
    Patent number: 4175080
    Abstract: 5'-Hydroxyleurosine, 5'-hydroxyleuroformine and related compounds, useful in inhibiting the growth of experimental tumors.
    Type: Grant
    Filed: August 2, 1978
    Date of Patent: November 20, 1979
    Assignee: Eli Lilly and Company
    Inventors: Gerald L. Thompson, Gloria C. Paschal, Robert A. Conrad
  • 5'-Hydroxyleurosine and related compounds
    Patent number: 4122081
    Abstract: 5'-Hydroxyleurosine, 5'-hydroxyleuoformine and related compounds, useful in inhibiting the growth of experimental tumors.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: October 24, 1978
    Assignee: Eli Lilly and Company
    Inventors: Gerald L. Thompson, Gloria C. Paschal, Robert A. Conrad
  • 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
    Patent number: 4115388
    Abstract: 3'-hydroxy and 3'-keto derivatives of 4'-deoxy VLB (deoxy VLB "A"), 4'-deoxyleurosidine (deoxy VLB "B"), 4'-deoxyvincristine and 4'-deoxy-1-desmethyl-1-formylleurosidine and related 4-desacetyl and C-3 carboxamide derivatives, useful as anti-tumor agents in mammals.
    Type: Grant
    Filed: March 30, 1977
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventors: Gerald L. Thompson, Gloria C. Paschal