Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: An optical assembly comprising a plurality of inputs comprising optical fibres which have a non-circular core cross-section, the fibres having a proximal end for receiving light from a respective diode emitter and a distal end, the fibres being combined at their distal ends and joined to a single output fibre which has a circular core cross-section, whereby in use light from a plurality of diode emitters is combined and output through the single output fibre.

Abstract: A termination for an optical fiber is disclosed, including an end cap optically connected to a delivery end of the fiber and tapering its towards its proximal end so as to expand the signal beam output by the fiber, a capillary having a bore mounted so that the end cap and an end portion of the delivery fiber are mounted within the bore, the capillary having an end which is angled so as to reflect undesired radiation within the capillary away from the fiber, and a cladding mode stripper arranged upstream of the delivery end.

Abstract: A fibre laser system is disclosed comprising an optical fibre, a part of which is doped with a rare earth to form an optical gain medium; at least one laser diode; means for applying pump radiation from the laser diode to the optical gain medium and for generating a laser beam and delivery fibre means for delivering a laser beam to a workpiece, wherein the fibre laser is provided with at least one means for protecting one or more components from damage caused by errant radiation. Several different means of protection are disclosed.

Abstract: A termination for an optical fibre is disclosed, including an end cap optically connected to a delivery end of the fibre and tapering its towards its proximal end so as to expand the signal beam output by the fibre, a capillary having a bore mounted so that the end cap and an end portion of the delivery fibre are mounted within the bore, the capillary having an end which is angled so as to reflect undesired radiation within the capillary away from the fibre, and a cladding mode stripper arranged upstream of the delivery end.

Abstract: A device for coupling multimode pump light and a laser signal into or out of a cladding-pumped fibre laser is disclosed, comprising an output optical fibre, a substantially un-tapered feed-through optical fibre, an annular waveguide having a tapered section, and a plurality of multimode pump fibres such that: the signal feed-through fibre is located within the annular waveguide; the signal feed-through fibre is fused into the annular waveguide in the tapered section so that the annular waveguide becomes an additional cladding layer of the feed-through fibre; the end of the feed-through fibre that is fused into the annular waveguide is optically coupled to the output optical fibre; the multimode pump fibres are optically coupled to the annular waveguide in the un-tapered section. Methods of forming the device are also disclosed.

Abstract: A gear pump arrangement comprising a pair of intermeshing gears (16, 18) located between bearing blocks (24) and rotatable to pump fluid from an inlet (12) to an outlet (14), wherein at least one of the bearing blocks (24) comprises a body (28) formed with a recess (32) within which an insert (34) is located, the recess (32) and insert (34) being shaped so as to be of smaller dimensions at a bearing surface (30) of the bearing block (24) than at a point remote therefrom.

Abstract: A fibre laser system is disclosed comprising an optical fibre, a part of which is doped with a rare earth to form an optical gain medium; at least one laser diode; means for applying pump radiation from the laser diode to the optical gain medium and for generating a laser beam and delivery fibre means for delivering a laser beam to a workpiece, wherein the fibre laser is provided with at least one means for protecting one or more components from damage caused by errant radiation. Several different means of protection are disclosed.

Abstract: A device for coupling multimode pump light and a laser signal into or out of a cladding-pumped fibre laser is disclosed, comprising an output optical fibre, a substantially un-tapered feed-through optical fibre, an annular waveguide having a tapered section, and a plurality of multimode pump fibres such that: the signal feed-through fibre is located within the annular waveguide; the signal feed-through fibre is fused into the annular waveguide in the tapered section so that the annular waveguide becomes an additional cladding layer of the feed-through fibre; the end of the feed-through fibre that is fused into the annular waveguide is optically coupled to the output optical fibre; the multimode pump fibres are optically coupled to the annular waveguide in the un-tapered section. Methods of forming the device are also disclosed.

Abstract: According to the present invention there is provided a fuel injection system for a combustion engine, comprising: a fuel metering unit for providing a metered supply of pressurized fuel, at least one first fuel injector, at least one second fuel injector, a fuel supply passage arrangement for supplying fuel from the fuel metering unit to the at least one first fuel injector and the at least one second fuel injector. The fuel supply passage arrangement including a first valve for controlling the flow of fuel from the fuel metering unit to the at least one second fuel injector. The first valve having a fuel inlet communicating with the fuel metering unit, a fuel supply outlet communicating with the at least one second injector.

Abstract: An hydraulic valve arrangement including a fluid pressure actuable valve which is actuable between a first position in which fluid flow through the fluid pressure actuable valve is prevented and a second position in which fluid flow through the fluid pressure actuable valve is permitted at a first rate. The hydraulic valve arrangement also includes a second valve which is actuable between an open state, in which fuel flows through the second valve at a second rate, and a closed state in which there is no flow through the second valve.

Abstract: A solid state laser, includes laser rod tubes (10, 117) crimped onto each end of a laser rod (15, 121) with PTFE seal rings (25, 118) compressed between the laser rod and the laser rod tube. The compressed seal rings provide an improved leak tight seal in a laser pumping chamber. Each laser rod tube (10) provides a mounting and holding area (20) for supporting the laser rod ends therein while protecting and sealing the end faces of the laser rod. A swaging tool (40) and method for swaging the laser rod tube (10) onto the laser rod (15) to provide a compression fit are provided. The compression seal and swaging method are usable in a variety of leak tight sealing applications.

Abstract: According to the present invention there is provided a fuel injection system for a combustion engine, comprising:

Abstract: A solid state laser, includes laser rod tubes (10, 117) crimped onto each end of a laser rod (15, 121) with PTFE seal rings (25, 118) compressed between the laser rod and the laser rod tube. The compressed seal rings provide an improved leak tight seal in a laser pumping chamber. Each laser rod tube (10) provides a mounting and holding area (20) for supporting the laser rod ends therein while protecting and sealing the end faces of the laser rod. A swaging tool (40) and method for swaging the laser rod tube (10) onto the laser rod (15) to provide a compression fit are provided. The compression seal and swaging method are usable in a variety of leak tight sealing applications.

Abstract: An hydraulic valve arrangement including a fluid pressure actuable valve which is actuable between a first position in which fluid flow through the fluid pressure actuable valve is prevented and a second position in which fluid flow through the fluid pressure actuable valve is permitted at a first rate. The hydraulic valve arrangement also includes a second valve which is actuable between an open state, in which fuel flows through the second valve at a second rate, and a closed state in which there is no flow through the second valve.

Abstract: A fluid flow system for supplying fuel to an engine, the system including a fluid flow valve having a valve element movable alternatively to a first operative position in which a relatively low fluid flow rate is permitted through the valve, for achieving a normal gradual shut-off of fuel supply, and a second operative position in which a relatively high fluid flow rate is permitted through the valve, for achieving a rapid emergency shut-off of fuel supply. Also disclosed is a fluid flow valve for use in the system. The invention has application in aircraft gas turbine engines.