Abstract: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.

Abstract: We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I), wherein: R5 is OH, alkoxy or alkanoyloxy; R6 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R12 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R16 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R17 is OH, alkoxy or alkanoyloxy; R18 is OH, alkoxy or alkanoyloxy; R21 is H, OH, CN or another nucleophilic group; and Ra is hydrogen and Rb is optionally substituted amino, or Ra with Rb form a carbonyl function ?O, or Ra, Rb and the carbon to which they are attached form a tetrahydroisoquinoline group.

Abstract: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.

Abstract: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.

Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumor long-chain, straight-chain alkane compounds which have a 2-amino group and a 3-hydroxy group. Compositions and methods comprising an isolated and purified long-chain, straight-chain 2-amino-3-hydroxyalkane, or prodrug thereof, and a pharmaceutically acceptable carrier are also described, wherein the carbon chain in the long-chain, straight-chain 2-amino-3-hydroxyalkane is C16-C24.

Abstract: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogues of kahalalide F, useful as antitumoral, antiviral, antifungal agents and in the treatment of psoriasis.

Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.

Abstract: Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies.

Abstract: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.

Abstract: The present invention is based upon the immunomodulatory activity of synthetic and semi-synthetic didemnin compounds. It has surprisingly been discovered that certain didemnin compounds possess unexpectedly high immunomodulation activity, and thus will be useful for modulating or regulating immunological functions in warm blooded animals. From the data provided herein it is believed that the physician will be able to determine the appropriate dosage of the immunosuppressant didemnins of the present invention. The actual dosage to be administered depends, inter alia, on the animal species to be treated, the subject animal's size, and the capacity of the subject to utilize the particular didemnin compound administered. Accordingly, the actual amounts of any didemnin compound required to be administered depend on the judgment of the practitioner.