Patents by Inventor Gnanasambandam Kumaravel

Gnanasambandam Kumaravel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINES AND METHODS OF THEIR USE
    Publication number: 20250197375
    Abstract: Disclosed are compounds comprising pyrimidinyl core and pharmaceutical compositions useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases, including FTLD-TDP, chronic traumatic encephalopathy, ALS, Alzheimer's disease, LATE, or frontotemporal lobar degeneration.
    Type: Application
    Filed: December 8, 2022
    Publication date: June 19, 2025
    Inventors: Gnanasambandam Kumaravel, Madeline Macdonnell, Hairuo Peng
  • BICYCLIC HETEROARENES AND METHODS OF THEIR USE
    Publication number: 20250145642
    Abstract: Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases, including frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), or frontotemporal lobar degeneration.
    Type: Application
    Filed: December 8, 2022
    Publication date: May 8, 2025
    Inventors: Gnanasambandam Kumaravel, Madeline Macdonnell, Hairuo Peng, Kerem Ozboya, Iwona Wrona, Bertrand Le Bourdonnec, Matthew Lucas, Vanessa Kuria, Byron DeLaBarre
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20240294524
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: April 11, 2024
    Publication date: September 5, 2024
    Inventors: Joseph ARNDT, Timothy CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • BRUTON'S TYROSINE KINASE INHIBITORS
    Publication number: 20240246988
    Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 9, 2023
    Publication date: July 25, 2024
    Inventors: Minna BUI, Patrick R. CONLON, Julio H. CUERVO, Daniel A. ERLANSON, Junfa FAN, Bing GUAN, Brian T. HOPKINS, Tracy J. JENKINS, Gnanasambandam KUMARAVEL, Alexey A. LUGOVSKOY, Doug MARCOTTE, Noel POWELL, Daniel SCOTT, Laura SILVIAN, Art TAVERAS, Deping WANG, Min ZHONG
  • Heteroaryl inhibitors of PAD4
    Patent number: 11897866
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: February 13, 2024
    Assignee: Padlock Therapeutics, Inc.
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Holly Atton, Edward Beaumont, Elise Gadouleau, Laura Gleave, Philip Stephen Kerry, Cristina Lecci, Mirco Meniconi, Nat Monck, Jordan Palfrey, Kostas Papadopoulos, Heather Tye, Philip A. Woods
  • Nucleic acid-binding photoprobes and uses thereof
    Patent number: 11807623
    Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 7, 2023
    Assignee: Arrakis Therapeutics, Inc.
    Inventors: Gnanasambandam Kumaravel, Jennifer C. Petter, Jonathan Craig Blain, Donovan Noel Chin, Chao Fang, Herschel Mukherjee, Neil Kubica
  • NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF
    Publication number: 20230312520
    Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
    Type: Application
    Filed: January 17, 2023
    Publication date: October 5, 2023
    Inventors: Gnanasambandam KUMARAVEL, Jennifer C. PETTER, Jonathan Craig BLAIN, Donovan Noel CHIN, Chao FANG, Herschel MUKHERJEE, Neil KUBICA
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20230113598
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: July 21, 2022
    Publication date: April 13, 2023
    Inventors: Joseph ARNDT, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cheng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt Van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • BRUTON'S TYROSINE KINASE INHIBITORS
    Publication number: 20230046457
    Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 12, 2022
    Publication date: February 16, 2023
    Inventors: Minna BUI, Patrick CONLON, Julio H. CUERVO, Daniel A. ERLANSON, Junfa FAN, Bing GUAN, Brian T. HOPKINS, Tracy J. JENKINS, Gnanasambandam KUMARAVEL, Alexey A. LUGOVSKOY, Doug MARCOTTE, Noel POWELL, Daniel SCOTT, Laura SILVIAN, Art TAVERAS, Deping WANG, Min ZHONG
  • Biaryl inhibitors of Bruton's tyrosine kinase
    Patent number: 11572356
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: February 7, 2023
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION
    Publication number: 20220402883
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 6, 2022
    Publication date: December 22, 2022
    Inventors: Russell C. PETTER, James Gregory BARSOUM, Gnanasambandam KUMARAVEL, Kenneth W. BAIR
  • BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20220332705
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: August 27, 2020
    Publication date: October 20, 2022
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • IRAK4 inhibiting agents
    Patent number: 11427561
    Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: August 30, 2022
    Assignee: BIOGEN MA INC.
    Inventors: Timothy Chan, Kevin M. Guckian, Tracy Jenkins, Jermaine Thomas, Jeffrey Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph P. Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield, Nathan Genung
  • HETEROARYL INHIBITORS OF PAD4
    Publication number: 20220081418
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Application
    Filed: November 9, 2021
    Publication date: March 17, 2022
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Holly Atton, Edward Beaumont, Elise Gadouleau, Laura Gleave, Philip Stephen Kerry, Cristina Lecci, Mirco Meniconi, Nat Monck, Jordan Palfrey, Kostas Papadopoulos, Heather Tye, Philip A. Woods
  • Heteroaryl inhibitors of PAD4
    Patent number: 11198681
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: December 14, 2021
    Assignee: Padlock Therapeutics, Inc.
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Holly Atton, Edward Beaumont, Elise Gadouleau, Laura Gleave, Philip Stephen Kerry, Cristina Lecci, Mirco Meniconi, Nat Monck, Jordan Palfrey, Kostas Papadopoulos, Heather Tye, Philip A. Woods
  • HETEROARYL INHIBITORS OF PAD4
    Publication number: 20210299115
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 30, 2021
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Cristina Lecci, Pui Leng Loke, Mirco Meniconi, Nathaniel Julius Thomas Monck, Carl Leslie North, Mark Peter Ridgill, Heather Tye
  • HETEROARYL INHIBITORS OF PAD4
    Publication number: 20210188810
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 24, 2021
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Holly Atton, Edward Beaumont, Elise Gadouleau, Laura Gleave, Philip Stephen Kerry, Cristina Lecci, Mirco Meniconi, Nat Monck, Jordan Palfrey, Kostas Papadopoulos, Heather Tye
  • IRAK4 INHIBITING AGENTS
    Publication number: 20210188809
    Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.
    Type: Application
    Filed: January 18, 2017
    Publication date: June 24, 2021
    Inventors: Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffrey Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph P. Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield, Nathan Genung
  • Heteroaryl inhibitors of PAD4
    Patent number: 11026937
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: June 8, 2021
    Assignee: Padlock Therapeutics, Inc.
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Cristina Lecci, Pui Leng Loke, Mirco Meniconi, Nathaniel Julius Thomas Monck, Carl Leslie North, Mark Peter Ridgill, Heather Tye
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20210070752
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: June 18, 2020
    Publication date: March 11, 2021
    Inventors: Joseph ARNDT, Timothy R. CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON