Abstract: The invention pertains to surface topographies which can be used to modulate the morphology, proliferation, biochemical functioning, differentiation, attachment, migration, signaling, and/or cell death of a cell population by physical stimulation. Such topographies can be applied in vitro and in vivo to modulate cell behavior. Specific examples include implants provided with a topography of the invention which regulates the immune response, or an implant which increases osteogenesis. The invention furthermore pertains to objects which are used in vitro to modulate cell behavior.