Patents by Inventor Godfrey W. Amphlett

Godfrey W. Amphlett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20230158168
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Application
    Filed: September 8, 2022
    Publication date: May 25, 2023
    Inventors: Yong DAI, Yong WANG, Shengjin JIN, Deborah H. MESHULAM, Godfrey W. AMPHLETT
  • Process for preparing purified drug conjugates
    Patent number: 11471536
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: October 18, 2022
    Assignee: IMMUNOGEN, INC.
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20190030177
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Application
    Filed: April 27, 2018
    Publication date: January 31, 2019
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • Process for preparing purified drug conjugates
    Patent number: 9789204
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: October 17, 2017
    Assignee: Immunogen, Inc.
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20160045616
    Abstract: The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step. holding steps, and optionally a tangential flow filtration (TFF) step.
    Type: Application
    Filed: October 28, 2015
    Publication date: February 18, 2016
    Inventors: Yong DAI, Yong WANG, Shengjin JIN, Deborah H. MESHULAM, Godfrey W. AMPHLETT, Ravi CHARI, Wei ZHANG
  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20150182635
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Application
    Filed: January 5, 2015
    Publication date: July 2, 2015
    Inventors: Yong DAI, Yong WANG, Shengjin JIN, Deborah H. MESHULAM, Godfrey W. AMPHLETT
  • Process for preparing purified drug conjugates
    Patent number: 8933205
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: January 13, 2015
    Assignee: ImmunoGen, Inc.
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • USE OF N-HYDROXYSUCCINIMIDE TO IMPROVE CONJUGATE STABILITY
    Publication number: 20140350228
    Abstract: The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability in the presence of exogenous NHS. In some embodiments, the inventive process comprises the addition of a molar ratio of exogenous NHS with respect to the amount of NHS generated during the modification reaction as a result of hydrolysis/aminolysis of the bifunctional linker.
    Type: Application
    Filed: December 13, 2012
    Publication date: November 27, 2014
    Applicant: ImmunoGen, Inc.
    Inventors: Fang Liu, Godfrey W. Amphlett, Deborah H. Meshulam
  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20130281678
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Application
    Filed: February 25, 2013
    Publication date: October 24, 2013
    Inventors: Yong DAI, Yong WANG, Shengjin JIN, Deborah H. MESHULAM, Godfrey W. AMPHLETT
  • Process for preparing purified drug conjugates
    Patent number: 8383122
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: February 26, 2013
    Assignee: ImmunoGen, Inc.
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
    Publication number: 20110021744
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Application
    Filed: October 8, 2010
    Publication date: January 27, 2011
    Applicant: ImmunoGen, Inc.
    Inventors: Yong DAI, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • Process for preparing purified drug conjugates
    Patent number: 7811572
    Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: October 12, 2010
    Assignee: ImmunoGen, Inc.
    Inventors: Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
  • Process for pasteurizing fibronectin
    Patent number: 4585654
    Abstract: A process for heating and simultaneously agitating a plasma protein solution in the presence of a polyol, a surface active agent and a chelating agent. Said process inactivates viruses in said solution while preserving the physical and biological properties of said plasma protein.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: April 29, 1986
    Assignee: Armour Pharmaceutical Co.
    Inventors: Ricardo H. Landaburu, Godfrey W. Amphlett, Roy E. Branson, Arthur B. Shaw
  • Process for purifying factor VIII:C
    Patent number: 4508709
    Abstract: Factor VIII:C is purified by chromatographic absorption on aminohexyl agarose at a pH above 5.5 up to about 8, and preferably 6.5 to 7.2, and a conductivity of about 25 to about 35 mS/cm.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: April 2, 1985
    Assignee: Armour Pharmaceutical Company
    Inventors: Godfrey W. Amphlett, Michael E. Hrinda