Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF ?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transforrnant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-&kgr;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr;B. Using plasmid pNF&kgr;B-Luc, cDNA encoding a protein capable of activating NF-&kgr;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr;B activation.

Abstract: Provided are proteins having NF-&kgr; B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr; B. Using plasmid pNF&kgr; B-Luc, cDNA encoding a protein capable of activating NF-&kgr; B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr; B activation.

Abstract: Provided are proteins having NF-&kgr;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr;B. Using plasmid pNF&kgr;B-Luc, cDNA encoding a protein capable of activating NF-&kgr;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr;B activation.

Abstract: Provided are proteins having NF-kB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-kB. Using plasmid pNFkB-Luc, cDNA encoding a protein capable of activating NF-kB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-kB activation.

Abstract: Proteins having activity that promotes STAT6 activation, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of STAT6 are provided. Using a STAT6 response reporter plasmid, cDNA encoding a protein capable of promoting STAT6 activation was cloned from the cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence are determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting STAT6 activation.