Patents by Inventor Gong-Li Tang

Gong-Li Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Patent number: 7452693
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 18, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang
  • DISCRETE ACYLTRANSFERASES ASSOCIATED WITH TYPE I POLYKETIDE SYNTHASES AND METHODS OF USE
    Publication number: 20080124757
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Application
    Filed: October 18, 2006
    Publication date: May 29, 2008
    Inventors: Ben SHEN, Yi-Qiang Cheng, Gong-Li Tang
  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Patent number: 7153667
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: December 26, 2006
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang
  • Leinamycin biosynthesis gene cluster and its components and their uses
    Publication number: 20050080247
    Abstract: This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus. The leinamycin gene cluster provides a hybrid polyketide synthase/nonribosomal peptide synthetase pathway. Elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for leinamycins, leinamycin analogs, and various other polyketides, peptides, and hybrid peptide-polyketide natural products.
    Type: Application
    Filed: March 22, 2002
    Publication date: April 14, 2005
    Inventors: Ben Shen, Yi-qiang Cheng, Gong-li Tang
  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Publication number: 20030175888
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Application
    Filed: December 9, 2002
    Publication date: September 18, 2003
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang