Patents by Inventor Gong-Xin He

Gong-Xin He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050124585
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 9, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050124584
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 9, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050009043
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: March 11, 2004
    Publication date: January 13, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Method and compositions for identifying anti-HIV therapeutic compounds
    Publication number: 20040121316
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: June 24, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Gabriel Birkus, James M. Chen, Xiaowu Chen, Tomas Cihlar, Eugene J. Eisenberg, Marcos Hatada, Gong-Xin He, Choung U. Kim, William A. Lee, Martin J. McDermott, Sundaramoorthi Swaminathan
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20030219727
    Abstract: A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity.
    Type: Application
    Filed: June 16, 2003
    Publication date: November 27, 2003
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
    Publication number: 20020119443
    Abstract: A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity.
    Type: Application
    Filed: July 20, 2001
    Publication date: August 29, 2002
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Triheterocyclic peptides capable of binding the minor and major grooves of DNA
    Patent number: 5698674
    Abstract: The present invention provides a triheterocyclic peptide having first, second, and third 5-member heterocyclic moieties having the following formula CR.sub.3 CONH--Q.sup.1 --CONH--Q.sup.2 --CONH--Q.sup.3 -CONH--(CR.sub.3).sub.S --B, wherein Q.sup.1 is selected from a group consisting of: ##STR1## wherein Q.sup.2 is selected from a group consisting of: ##STR2## wherein Q.sup.3 is selected from a group consisting of: ##STR3## wherein at least one of A and Z is other than C; wherein A is C, N, O, or S; wherein B is N(CR.sub.3).sub.n or C(NH.sub.2).sub.2 ; wherein n is an integer from 2 to 10; wherein P is H, a lower alkyl or a halogen; wherein Q1, Q2, and Q3 are the same or different; wherein R is H, a lower alkyl group; wherein S is an integer from 1 to 10; wherein X' represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.n --CR.sub.2 Y; wherein X" represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.n --CR.sub.2 Y; wherein X'" represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: December 16, 1997
    Assignee: The Regents of the University of California
    Inventors: Thomas C. Bruice, Kenneth A. Browne, Gong-Xin He