Abstract: The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype.

Abstract: The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype.

Abstract: The invention discloses a liquid oxygen storage tank, which includes an outer tank body, a buffer cavity is provided in the outer tank body, and an insulation tank with an upper end extending outside the buffer cavity is provided in the buffer cavity, and the buffer chamber is provided in the buffer tank. There is a buffer mechanism for reducing the impact force of the tank body. The thermal insulation tank is internally provided with an internal tank body, the internal tank body is provided with a storage cavity, and the upper end of the thermal insulation tank is provided with a control cavity. A driving block is arranged in the cavity. The invention adopts a high-vacuum multi-layer thermal insulation technology to prolong the number of days for holding liquid oxygen, and a heat preservation mechanism makes the storage time of liquid oxygen longer, and it is safer and more convenient to operate. If it is too high, it will start automatically and discharge excess gas to enhance the safety of use.

Abstract: The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype.

Abstract: Methods and compositions for reducing the expression of Rho-associated, coiled-coil containing protein kinase 2 (ROCK-II) are provided.

Abstract: Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided.