Patents by Inventor Gonzalo González de Buitrago
Gonzalo González de Buitrago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8951982Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof of an effective amount of one or more siNAs of the invention.Type: GrantFiled: January 18, 2013Date of Patent: February 10, 2015Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Publication number: 20140018527Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof of an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: January 18, 2013Publication date: January 16, 2014Applicant: Sylentis S.A.UInventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8389490Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: September 2, 2010Date of Patent: March 5, 2013Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8258110Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: September 4, 2012Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8252758Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: August 28, 2012Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8252759Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: August 28, 2012Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8247386Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: August 21, 2012Assignee: Sylentis SAUInventors: Ana I. Jiménez, Ángela Sesto, Irene Gaseón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8247387Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: August 21, 2012Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8198250Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: July 9, 2008Date of Patent: June 12, 2012Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Patent number: 8030284Abstract: Sequences and protocols for treatment of eye conditions by use of RNA interference are disclosed. Target genes are selected from those responsible for aqueous flow or aqueous outflow, while particularly preferred conditions to be treated include glaucoma and uveitis.Type: GrantFiled: August 23, 2005Date of Patent: October 4, 2011Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, José P. Roman, Irene Gascón, Gonzalo González de Buitrago
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Patent number: 7902169Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: September 21, 2009Date of Patent: March 8, 2011Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Publication number: 20100331394Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: September 2, 2010Publication date: December 30, 2010Applicant: Sylentis S.A.U.Inventors: Ana I. Jiménez, Angela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Publication number: 20100022623Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: September 21, 2009Publication date: January 28, 2010Applicant: Sylentis S.A.U.Inventors: Ana I. Jiménez, Ángela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Publication number: 20090264501Abstract: Methods and compositions for the downregulation of P2X7 receptor expression or activity are disclosed. Preferred compositions comprise siNA. The methods and compositions are useful in the treatment of diseases characterised by increased 112X7 receptor activity, such as neuronal degeneration, Alzheimer's disease, inflammatory diseases, and some cancers.Type: ApplicationFiled: August 30, 2005Publication date: October 22, 2009Applicant: Sylentis S.A.Inventors: Ana I. Jimenez, Angela Sesto, Jose P. Roman, Irene Gascon, Gonzalo Gonzalez De Buitrago, Maria C. Jimenez
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Patent number: 7592325Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: GrantFiled: February 22, 2006Date of Patent: September 22, 2009Assignee: Sylentis S.A.U.Inventors: Ana I. Jiménez, Angela Sesto, Irene Gascón, José P. Román, Gonzalo González de Buitrago
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Publication number: 20090105175Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: July 9, 2008Publication date: April 23, 2009Applicant: Sylentis S.A.U.Inventors: Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
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Publication number: 20090105176Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: July 9, 2008Publication date: April 23, 2009Applicant: Sylentis S.A.U.Inventors: Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
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Publication number: 20090099113Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: July 9, 2008Publication date: April 16, 2009Applicant: Sylentis S.A.UInventors: Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
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Publication number: 20090099114Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: July 9, 2008Publication date: April 16, 2009Applicant: Sylentis S.A.U.Inventors: Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago
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Publication number: 20090099112Abstract: The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.Type: ApplicationFiled: July 9, 2008Publication date: April 16, 2009Applicant: Sylentis S.A.U.Inventors: Ana I. Jimenez, Angela Sesto, Irene Gascon, Jose P. Roman, Gonzalo Gonzalez de Buitrago