Patents by Inventor Gonzalo Hortelano

Gonzalo Hortelano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120282343
    Abstract: The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 8, 2012
    Applicant: Johns Hopkins University
    Inventors: Kam W. Leong, Grace Okoli, Gonzalo Hortelano
  • Publication number: 20110301097
    Abstract: The present invention is directed toward a composition for widespread distribution, systemic expression and sustained delivery of a therapeutic agent and to a process for administration of a therapeutic agent via a natural gastrointestinal pathway. More particularly, the invention discloses a composition for the administration of oral gene therapy and a process for its production and use.
    Type: Application
    Filed: August 17, 2011
    Publication date: December 8, 2011
    Inventors: Gonzalo Hortelano, Andrew Gomez Vargas
  • Publication number: 20060178336
    Abstract: The present invention is directed toward a method for the induction of tolerance to a foreign transgene or a self-antigen in an animal host by administration of a composition to an animal host via a natural gastrointestinal pathway. Additionally, the present method can eliminate a pre-existing immune response in an animal host. The composition administered when carrying out the method achieves widespread distribution, systemic expression and sustained delivery of a genetic material in an animal host. More particularly, the invention discloses a method useful for both eliciting tolerance and for abrogation of a pre-existing immune response by oral administration of a genetic material.
    Type: Application
    Filed: April 6, 2006
    Publication date: August 10, 2006
    Inventors: Gonzalo Hortelano, Andrew Vargas
  • Publication number: 20060051424
    Abstract: The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy.
    Type: Application
    Filed: October 3, 2002
    Publication date: March 9, 2006
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventors: Kam Leong, Grace Okoli, Gonzalo Hortelano
  • Publication number: 20060030540
    Abstract: The present invention is directed toward a method of producing transgenic animals by administration of a composition to an animal via a natural gastrointestinal pathway. The composition achieves widespread distribution, systemic expression and sustained delivery in the animal. More particularly, the invention discloses a method for producing a transgenic animal using oral gene therapy. The present invention also provides transgenic animals produced by this method.
    Type: Application
    Filed: October 6, 2005
    Publication date: February 9, 2006
    Applicant: Neox, Inc.
    Inventors: Gonzalo Hortelano, Andrew Vargas
  • Publication number: 20050208032
    Abstract: The present invention is directed toward a composition for widespread distribution, systemic expression and sustained delivery of a therapeutic or transdifferentiating agent and to a process for administration of said agent via a natural gastrointestinal pathway. More particularly, the invention discloses a composition for the administration of oral gene therapy and a process for its production and use.
    Type: Application
    Filed: January 18, 2005
    Publication date: September 22, 2005
    Inventors: Gonzalo Hortelano, Gomez Vargas
  • Publication number: 20040014704
    Abstract: The present invention is directed toward a method for the induction of tolerance to a foreign transgene or a self-antigen in an animal host by administration of a composition to an animal host via a natural gastrointestinal pathway. Additionally, the present method can eliminate a pre-existing immune response in an animal host. The composition administered when carrying out the method achieves widespread distribution, systemic expression and sustained delivery of a genetic material in an animal host. More particularly, the invention discloses a method useful for both eliciting tolerance and for abrogation of a pre-existing immune response by oral administration of a genetic material.
    Type: Application
    Filed: December 18, 2002
    Publication date: January 22, 2004
    Inventors: Gonzalo Hortelano, Andrew Gomez Vargas
  • Publication number: 20040016013
    Abstract: The present invention is directed toward a method of producing transgenic animals by administration of a composition to an animal via a natural gastrointestinal pathway. The composition achieves widespread distribution, systemic expression and sustained delivery in the animal. More particularly, the invention discloses a method for producing a transgenic animal using oral gene therapy. The present invention also provides transgenic animals produced by this method.
    Type: Application
    Filed: December 18, 2002
    Publication date: January 22, 2004
    Inventors: Gonzalo Hortelano, Andrew Gomez Vargas
  • Publication number: 20040014698
    Abstract: The present invention is directed toward a composition for widespread distribution, systemic expression and sustained delivery of a therapeutic agent and to a process for administration of a therapeutic agent via a natural gastrointestinal pathway. More particularly, the invention discloses a composition for the administration of oral gene therapy and a process for its production and use.
    Type: Application
    Filed: July 18, 2002
    Publication date: January 22, 2004
    Inventors: Gonzalo Hortelano, Andrew Gomez Vargas
  • Publication number: 20040005302
    Abstract: The present invention provides a novel approach to vaccination and/or treatment using encapsulated cells for eliciting immune responses. More specifically, the present invention is to provide a method or process for inducing an immune response in a host, wherein the process comprises the steps of: enclosing genetically engineered antigen-producing cells comprising one or more transgene, into an immunoisolating implantable device to provide encapsulated antigen-producing cells; introducing the encapsulated antigen-producing cells in the host; production of the transgene antigen product; bi-directional passage of the produced antigen product through the pores of the microcapsules, with preclusion of the passage of the antigen-producing cells therethrough; delivery of a continuous infusion of antigen to the host; activation of the immune system in response to the antigen.
    Type: Application
    Filed: April 30, 2003
    Publication date: January 8, 2004
    Inventor: Gonzalo Hortelano