Patents by Inventor Gonzalo Moratorio

Gonzalo Moratorio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA virus attenuation by alteration of mutational robustness and sequence space
    Patent number: 10206994
    Abstract: The application generally relates to the attenuation of a RNA virus or of a clone thereof and involves the alteration of sequence space, more particularly the reduction, of mutational robustness of said RNA virus or clone. The means of the application are more particularly dedicated to the attenuation of an infectious RNA virus or clone, for the production of immunogenic composition or vaccine. More particularly, the means of the application involve the replacement of codon(s) by different codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP, more particularly by different but synonymous codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 19, 2019
    Assignee: INSTITUT PASTEUR
    Inventors: Marco Vignuzzi, Cyril Barbezange, Gonzalo Moratorio