Abstract: The present invention relates to an anti-EMAP II antibody or an antigen-binding fragment thereof, a nucleic acid molecule for coding the same, or a preparation method thereof. Also, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in preventing, treating or diagnosing EMAP II-mediated diseases, for example, TNF-?-mediated disease or Alzheimer's disease. Furthermore, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in detecting or quantifying an EMAP II antigen. The antibody of the present invention may exhibit a more improved antigen-binding capacity compared to existing anti-EMAP antibodies and may treat the TNF-?-mediated disease more effectively.

Abstract: The present invention provides a cage holder for a spinal fusion cage which is mounted on the spinal fusion cage, thereby allowing the spinal fusion cage to be stably inserted between vertebral bodies. The cage holder may be engaged with the spinal fusion cage to insert the spinal fusion cage between the vertebral bodies at the lowest height, and may be reliably separated from the spinal fusion cage after the surgery. In addition, when mounting the cage holder on a height adjustable spinal fusion cage, the cage holder may visually indicate an amount of change in the height of the spinal fusion cage.

Abstract: The present invention provides a spinal fusion cage that can be inserted between vertebral bodies at the lowest height, and the height thereof may be adjusted with being inserted, such that cages having different heights within a certain range may be replaced by one cage. Therefore, the number of product groups that should be produced is reduced and the amount in stock is also decreased on the manufacturer. In addition, unlike the cage having a predetermined height at a constant interval in the prior art, the height of the spinal fusion cage is linearly adjusted according to a spacing between vertebral bodies of a patient, such that the surgery may be performed at the optimal height according to spinal conditions of the patient.

Abstract: The present invention relates to a surgical screw capable of self-locking and a fusion device using the same. The screw includes: a screw body having a body main thread formed on an outer circumferential surface thereof, a body locking thread spaced apart from the body main thread with an offset portion interposed therebetween, and a body driving groove formed in the upper portion thereof; and a sleeve having a sleeve thread formed on an inner circumferential surface thereof to be screwed with the body locking thread, and a sleeve stopper spaced downwards from the sleeve thread so as to support the body locking thread. The surgical screw may also be included in a fusion device in a different form by coupling with a plate or a cage.

Abstract: The present invention relates to a surgical screw capable of self-locking and a fusion device using the same. The surgical screw includes: a screw body having a body thread formed on an outer circumferential surface thereof, and a body driving groove formed in an upper portion thereof; and a head part rotatably fixed with respect to the screw body so as to be moved in an axial direction of the screw body, wherein, when the head part rotates relative to the screw body, the head part is spaced apart from the screw body with a predetermined distance, thereby causing the threads of the head part and the screw body to become discontinuous, and thus the surgical screw is brought into a locked state. The surgical screw may also be included in a fusion device in a different form by coupling with a plate or a cage.

Abstract: The present invention provides a bone fusion device which allows a distant bone body in a surgery direction to be pulled toward an adjacent bone body in the surgery direction while fusing the adjacent bone bodies. The bone fusion device includes a bone screw which includes a shank having an elongated shape with a circular cross-section, a screw thread formed on one end portion of the shank, and an adjustment female thread formed in the other end portion of the shank; a washer which includes a through hole into which the other end portion of the shank is inserted, and has a cross-sectional area larger than that of the bone screw; and an adjustment screw having an adjustment male thread screwed with the adjustment female thread of the bone screw through a through hole of the washer.

Abstract: The present invention relates to an anti-EMAP II antibody or an antigen-binding fragment thereof, a nucleic acid molecule for coding the same, or a preparation method thereof. Also, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in preventing, treating or diagnosing EMAP II-mediated diseases, for example, TNF-?-mediated disease or Alzheimer's disease. Furthermore, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in detecting or quantifying an EMAP II antigen. The antibody of the present invention may exhibit a more improved antigen-binding capacity compared to existing anti-EMAP antibodies and may treat the TNF-?-mediated disease more effectively.

Abstract: The present invention relates to a surgical screw capable of self-locking and a fusion device using the same. The surgical screw includes: a screw body having a body thread formed on an outer circumferential surface thereof, and a body driving groove formed in an upper portion thereof; and a head part rotatably fixed with respect to the screw body so as to be moved in an axial direction of the screw body, wherein, when the head part rotates relative to the screw body, the head part is spaced apart from the screw body with a predetermined distance, thereby causing the threads of the head part and the screw body to become discontinuous, and thus the surgical screw is brought into a locked state. The surgical screw may also be included in a fusion device in a different form by coupling with a plate or a cage.

Abstract: The present invention relates to a surgical screw capable of self-locking and a fusion device using the same. The screw includes: a screw body having a body main thread formed on an outer circumferential surface thereof, a body locking thread spaced apart from the body main thread with an offset portion interposed therebetween, and a body driving groove formed in the upper portion thereof; and a sleeve having a sleeve thread formed on an inner circumferential surface thereof to be screwed with the body locking thread, and a sleeve stopper spaced downwards from the sleeve thread so as to support the body locking thread. The surgical screw may also be included in a fusion device in a different form by coupling with a plate or a cage.

Abstract: The present invention provides a bone fusion device which allows a distant bone body in a surgery direction to be pulled toward an adjacent bone body in the surgery direction while fusing the adjacent bone bodies. The bone fusion device includes a bone screw which includes a shank having an elongated shape with a circular cross-section, a screw thread formed on one end portion of the shank, and an adjustment female thread formed in the other end portion of the shank; a washer which includes a through hole into which the other end portion of the shank is inserted, and has a cross-sectional area larger than that of the bone screw; and an adjustment screw having an adjustment male thread screwed with the adjustment female thread of the bone screw through a through hole of the washer.

Abstract: A screw for fixing vertebra for letting a patient perform spinal motion more smoothly after a pedicle screw insertion surgery is disclosed. A head portion of the screw body is pivotally joined in sliding contact on the head seat portion of a movable washer, which is also pivotally joined in sliding contact on the washer seat portion of a fastening nut. A first aperture and a second aperture are formed in the fastening nut and movable washer respectively, and an elongating portion without a thread is formed between a screw portion and the head portion of the screw body.

Abstract: The present invention relates to a method for manufacturing an in vitro vascularized tissue, which enables obtaining the in vitro vascularized tissue by inducing in vitro angiogenesis in a tissue using vascular cells, for use in in vitro research of diseases in vascularized tissues and developing a treatment. The method for manufacturing the in vitro vascularized tissue comprises the steps of: supplying a hydrogel to cover the vascularized tissue cells; molding the same to form a supply hole, which is separated from the vascularized tissue cells, on the upper side of the hydrogel; and supplying vascular cells to the supply hole.

Abstract: The present invention relates to a method for manufacturing an in vitro vascularized tissue, which enables obtaining the in vitro vascularized tissue by inducing in vitro angiogenesis in a tissue using vascular cells, for use in in vitro research of diseases in vascularized tissues and developing a treatment. The method for manufacturing the in vitro vascularized tissue comprises the steps of: supplying to a container for manufacturing tissue a hydrogel in which vascularized tissue cells are mixed; submerging a collection tip to which vascular cells are coupled into the hydrogel; hardening the hydrogel while the collection tip is submerged; and supplying a cell culture fluid to the upper side of the hydrogel.