Patents by Inventor Goran Akerstrom

Goran Akerstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for assessing and treating adrenal diseases and disorders
    Patent number: 9982026
    Abstract: The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an adrenal disease or disorder.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: May 29, 2018
    Assignee: YALE UNIVERSITY
    Inventors: Richard P. Lifton, Bixiao Zhao, Murim Choi, Goran Akerstrom, Gunnar Westin, Peyman Bjorklund, Per Hellman
  • Compositions and Methods for Assessing and Treating Adrenal Diseases and Disorders
    Publication number: 20140127126
    Abstract: The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an adrenal disease or disorder.
    Type: Application
    Filed: January 4, 2012
    Publication date: May 8, 2014
    Applicant: Yale University
    Inventors: Richard P. Lifton, Bixiao Zhao, Murim Choi, Goran Akerstrom, Gunnar Westin, Peyman Bjorklund, Per Hellman
  • Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment
    Publication number: 20080227734
    Abstract: A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of diagnosing, prognosing and treating LRP5 related diseases, specifically hyperthyroidism and parathyroid tumors, and kits suitable for rapid on-site testing. Finally, methods of screening for agents capable of modulating the mutant LRP5 or LRP6 receptor proteins and pharmaceutical compositions comprising the selected agents.
    Type: Application
    Filed: November 24, 2004
    Publication date: September 18, 2008
    Inventors: Gunnar Westin, Peyman Bjorklund, Goran Akerstrom
  • Nucleic acids encoding human calcium sensor protein
    Patent number: 6239270
    Abstract: The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 29, 2001
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Göran Akerström, Claes Juhlin, Lars Rask, Göran Hjälm, Clarence C. Morse, Edward M. Murray, Gregg R. Crumley
  • Methods using human calcium sensor protein, fragments thereof and DNA encoding same
    Patent number: 6187548
    Abstract: The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: February 13, 2001
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Göran Akerström, Claes Juhlin, Lars Rask, Göran Hjälm, Clarence C. Morse, Edward M. Murray, Gregg R. Crumley
  • Antiparathyroid antibodies which specifically bind to cell surface molecules on parathyroid, renal and cytotrophoblast cells which are involved in calcium sensing
    Patent number: 5476921
    Abstract: Antibody preparations are useful in the prognosis of parathyroid and renal disorders. The antibody preparation includes antibodies which bind specifically to a surface antigen, Ca.sup.2+ sensing structure, present in humans on the parathyroid, on the proximal tubuli of the kidney, on the cytotrophoblastic cells of the placenta, on renal carcinoma cells and on parathyroid cancer cells.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: December 19, 1995
    Inventors: Claes Juhlin, Rikard Holmdahl, Lars Klareskog, Jonas Rastad, Goran Akerstrom