Patents by Inventor Goran B. Stening
Goran B. Stening has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5506215Abstract: A 2',3'-deoxy-3'-fluoro-pyrimidine nucleoside having the formula: ##STR1## wherein R.sup.1 is OH or NH.sub.2 ;R.sup.2 is CF.sub.3, CH.sub.2 CH.sub.2 CH.sub.3, ##STR2## CH.sub.2 OCH.sub.3, CH.sub.2 SCH.sub.3, CH.dbd.CH.sub.2 CH.dbd.CH--CH.sub.3, C.tbd.CH, C.tbd.C--CH.sub.3 or CH.sub.2 --C.tbd.CH;or a pharmaceutically acceptable salt thereof.These nucleoside analogs exhibit antiviral activity against HIV.Type: GrantFiled: December 12, 1994Date of Patent: April 9, 1996Assignee: Medivir ABInventors: Karl N. G. Johansson, BjoG. Lindborg, Ulf Norinder, Goran B. Stening
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Patent number: 5446029Abstract: Use of a compound of the formula ##STR1## wherein Base is thymine, Cytosine, adenine or guanine, or a physiologically acceptable salt thereof, for therapeutic treatment of hepatitis B virus infections and to a method for such treatment.Type: GrantFiled: September 9, 1993Date of Patent: August 29, 1995Assignee: Medivir ABInventors: Bertil F. H. Eriksson, Karl N. G. Johansson, Goran B. Stening, Bo F. Oberg
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Patent number: 5409906Abstract: A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows:A: ##STR2## X: (a) O (b) S(c) CH.sub.2R.sup.1 : H; alkyl containing 1-3 carbon atoms;--CH.dbd.CH.sub.2 ; --CH.dbd.CH--CH.sub.3 ; --CH.sub.2 --CH.dbd.CH.sub.2 ; ##STR3## --C.tbd.CH p1 R.sup.2 : H; or R.sup.2 constitutes together with R.sup.3 a carbon--carbon bondR.sup.3 : H; F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 ; CH.sub.2 OH; and when R.sup.3 is F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 or CH.sub.2 OH it may have either the cis-configuration or trans-configuration relative to the hydroxymetyl function at position 4', or R.sup.3 constitutes together with R.sup.2 a carbon--carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.Type: GrantFiled: April 1, 1993Date of Patent: April 25, 1995Assignee: Medivir ABInventors: Roelf Datema, Zsuzanna M. I. Kovacs, Karl N. G. Johansson, Bjorn Lindborg, Goran B. Stening, Bo. F. Oberg
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Patent number: 5215970Abstract: A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows: ##STR2## R.sup.2 : H; or R.sup.2 constitutes together with R.sup.3 with a carbon - carbon bondR.sup.3 : H; F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 ; CH.sub.2 OH; and when R.sup.3 is F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 or CH.sub.2 OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R.sup.3 constitutes together with R.sup.2 a carbon - carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV infections.Type: GrantFiled: November 20, 1991Date of Patent: June 1, 1993Assignee: Medivir ABInventors: Roelf Datema, Zsuzanna M. I. Kovacs, Karl N. G. Johansson, Bjorn G. Lindborg, Goran B. Stening, Bo F. Oberg
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Patent number: 5215971Abstract: Use of a compound of the formula ##STR1## wherein A is .beta.-2'-deoxy-D-ribofuranosyl or .beta.-D-arabinofuranosyl;R.sup.1 is hydroxy or amino;R.sup.2 is cycloalkyl or alkyl-substituted cycloalkyl containing 1-5 carbon atoms; saturated or unsaturated, straight or branched alkyl containing 1-5 carbon atoms which may be unsubstituted or substituted with halogen, hydroxy, mercapto, trifluoroalkyl or difluoroalkyl containing 1-3 carbon atoms, phenoxy or alkoxy containing 1-3 carbon atoms; phenyl or phenylalkyl containing 1-3 carbon atoms in the alkyl part, or a physiologically acceptable salt thereof,for manufacture of a medicament for therapeutic or prophylactic control or treatment of retrovirus, especially HIV, or hepatitis B virus infections in animal and man and to a method of such treatment.Type: GrantFiled: July 2, 1991Date of Patent: June 1, 1993Assignee: Medivir ABInventors: Roelf Datema, Kristina B. Gotthammar, Karl N. G. Johansson, Zsuzsanna M. I. Kovacs, Bjorn G. Lindborg, Goran B. Stening, Bo F. berg
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Patent number: 5036071Abstract: Antivirally active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxymethyl;R.sub.2 is hydrogen, hydroxy or hydroxymethyl;R.sub.3 is hydrogen; or R.sub.1 and R.sub.3 together constitute an additional carbon-carbon bond;with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydroxy or hydroxymethyl, that when R.sub.1 is hydroxymethyl then R.sub.2 is hydrogen and that when R.sub.2 is hydroxy then R.sub.1 is hydrogen; and physiologically acceptable salts; geometric or optical isomers thereof; processes for preparation of said compounds, pharmaceutical preparations containing the compounds, methods for treatment of virus infections and medical use of the compounds.Type: GrantFiled: January 22, 1988Date of Patent: July 30, 1991Assignee: Medivir ABInventors: Karl N. G. Johansson, Zsuzsanna M. I. Kovacs, Bjorn G. Lindborg, Goran B. Stening
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Patent number: 4771041Abstract: A method for the selective treatment of virus infections in animals and man comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.Type: GrantFiled: October 31, 1985Date of Patent: September 13, 1988Assignee: Astra Lakemedel AktiebolagInventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, deceased, Karl H. Misiorny, legal representive, Goran B. Stening, Stig-Ake A. Stridh
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Patent number: 4665062Abstract: A method for the selective treatment of virus infections in animals and man and a method of treating cancer caused by viruses, comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.Type: GrantFiled: August 2, 1982Date of Patent: May 12, 1987Assignee: Astra Lakemedel AktiebolagInventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, Goran B. Stening, Stig A. Stridh
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Patent number: 4591583Abstract: A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and each is selected from the group consisting of hydrogen, alkyl groups containing 1-6 carbon atoms; cycloalkyl groups containing 3-6 carbon atoms; cycloalkyl-alkyl groups containing 4-6 carbon atoms; 1-adamantyl; 2-adamantyl, benzyl; and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together form a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring; and R.sub.Type: GrantFiled: December 17, 1982Date of Patent: May 27, 1986Assignee: Astra Lakemedel AktiebolagInventors: Ake J. E. Helgstrand, Karl N. Johansson, Alfons Misiorny, Jan O. Noren, Goran B. Stening
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Patent number: 4536400Abstract: A compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different, and each is selected from the group consisting of hydrogen and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms; and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together form a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring; provided that one of R.sub.1 and R.sub.2 is a phenyl group of the formula II when R.sub.3 is H; and physiologically acceptable salts and optical isomers thereof; methods for preparation of the compounds, pharmaceutical compositions containing them, and their medicinal use.Type: GrantFiled: September 10, 1982Date of Patent: August 20, 1985Assignee: Astra Lakemedel AktiebolagInventors: .ANG.ke J. E. Helgstrand, Karl N. G. Johansson, Alfons Misiorny, Jan O. Noren, Goran B. Stening
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Patent number: 4495190Abstract: Novel antiviral compounds of the formula ##STR1## wherein each of R.sub.1 and R.sub.2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R.sub.1 or R.sub.2 is hydrogen when R.sub.1 and R.sub.2 are different, and provided that R.sub.1 and R.sub.2 are hydroxy or fluoro when R.sub.1 and R.sub.2 are the same; or a physiologically acceptable salt or an optical isomer thereof, methods for their preparation, pharmaceutical preparations containing the compounds, and methods for the treatment of virus infections and other diseases caused by viruses.Type: GrantFiled: October 25, 1982Date of Patent: January 22, 1985Assignee: Astra Lakemedel AktiebolagInventors: Curt-Erik Hagberg, Karl N. Johansson, Zsuzsanna M. I. Kovacs, Goran B. Stening
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Patent number: 4386081Abstract: A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and each is selected from the group consisting of hydrogen, alkyl groups containing 1-6 carbon atoms; cycloalkyl groups containing 3-6 carbon atoms; cycloalkyl-alkyl groups containing 4-6 carbon atoms; 1-adamantyl; 2-adamantyl, benzyl; and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together form a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring;and R.sub.Type: GrantFiled: November 13, 1979Date of Patent: May 31, 1983Assignee: Astra Lakemedel AktiebolagInventors: Ake J. E. Helgstrand, Karl N. Johansson, Alfons Misiorny, Jan O. Noren, Goran B. Stening
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Patent number: 4339445Abstract: A method for the selective treatment of virus infections in animals and man and a method of treating cancer caused by viruses, comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.Type: GrantFiled: December 21, 1978Date of Patent: July 13, 1982Assignee: Astra Lakemedel AktiebolagInventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, Goran B. Stening, Stig-Ake A. Stridh
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Patent number: 4215113Abstract: A method for the selective treatment of virus infections in animals and man, comprising administering to a host so infected a therapeutically effective amount of phosphonoformic acid or a physiologically acceptable salt thereof.Type: GrantFiled: June 20, 1977Date of Patent: July 29, 1980Assignee: Astra Lakemedel AktiebolagInventors: Bertil F. H. Eriksson, Ake J. E. Helgstrand, Alfons Misiorny, Goran B. Stening, Stig-Ake A. Stridh