Abstract: The present invention relates to antibody compositions directed to Interleukin 1 Receptor Accessory Protein (IL1RAP) and their use in the treatment and diagnosis of diseases associated with IL1RAP, such as inflammatory, autoimmune, autoinflammatory and neoplastic disorders.

Abstract: The present invention relates to antibody compositions directed to Interleukin 1 Receptor Accessory Protein (IL1RAP) and their use in the treatment and diagnosis of diseases associated with IL1RAP, such as inflammatory, autoimmune, autoinflammatory and neoplastic disorders.

Abstract: A system performs load balancing. The system receives a protocol message by a load balancer in communication with a distributed system comprising a server cluster. The system determines a cluster member to process the protocol message, where the cluster member is a member of the server cluster configured to own a state corresponding to the protocol message. The system then forwards the protocol message to the cluster member.

Abstract: In accordance with various embodiments, a set of features are described for enabling an application server platform for telecom based applications. A system for providing an application server for telecom-based applications can include a computer, including a computer readable medium and processor. The system can also include an application server, executing on the computer. The application server can include an actor container that manages and provides lifecycle and runtime properties for application classes that are executed as actors in the application server. The actor container can manages a set of event transactions, wherein all storage operations are performed as part of the event transaction that spans each event handler invocation.

Abstract: A system performs load balancing. The system receives a protocol message by a load balancer in communication with a distributed system comprising a server cluster. The system determines a cluster member to process the protocol message, where the cluster member is a member of the server cluster configured to own a state corresponding to the protocol message. The system then forwards the protocol message to the cluster member.

Abstract: In accordance with various embodiments, systems and methods are provided for co-locating execution logic and state data in a distributed and clustered environment. Such a system can include a plurality of applications, executing on one or more application servers, including an event broker which identifies state data required by an actor, a database which identifies an application server where such state data is cached; and a co-location module which instantiates the actor on the application server where such state data is cached. The method includes identifying state data required by a transaction, identifying an application server where such state data is cached, instantiating execution logic for processing the transaction on the application server where such state data is cached, and executing said execution logic for processing the transaction on the application server where such state data is cached thereby providing predictable low execution latency.

Abstract: This invention relates to a feed out device relating to a reversible feeder tube, i.e. a reclaimer, intended for bulk product, in particular a feeder tube, which includes a cylindrical drum or tube in which there are accommodated a large number of inlet openings distributed along the length of the tube, and a screw conveyor disposed coaxially with the tube within the tube. A device is provided for rotating the tube about its axis, and a device for rotating the screw conveyor relative to the tube. A device is provided for moving the feeder tube in the lateral direction, within a silo arrange to feed out bulk product into an outlet space, wherein an outer end of the feeder tube protrudes through an opening in the silo into a side space. The tube has at least one inlet opening disposed in the space. Adjacent the outer end there is arranged a feeding device arranged to assist in feeding bulk material into the inlet.

Abstract: In accordance with various embodiments, systems and methods are provided for co-locating execution logic and state data in a distributed and clustered environment. Such a system can include a plurality of applications, executing on one or more application servers, including an event broker which identifies state data required by an actor, a database which identifies an application server where such state data is cached; and a co-location module which instantiates the actor on the application server where such state data is cached. The method includes identifying state data required by a transaction, identifying an application server where such state data is cached, instantiating execution logic for processing the transaction on the application server where such state data is cached, and executing said execution logic for processing the transaction on the application server where such state data is cached thereby providing predictable low execution latency.

Abstract: The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.

Abstract: A service access gateway is described that provides enforcement of service level agreements across geographically remote domains. Each domain can comprise an access tier and a network tier that can be scaled by adding or removing server nodes. At the network tier level, a master node can be selected in each domain in order to maintain budget state information for the domain. Additionally, a global master can be elected in order to maintain the state information across multiple domains such that the service level agreements can be enforced in a synchronized manner. A geographical configuration service can also be implemented to generate alarms in cases where service level agreements across the multiple sites are not identical.

Abstract: In accordance with various embodiments, a set of features are described for enabling an application server platform for telecom based applications. A system for providing an application server for telecom-based applications can include a computer, including a computer readable medium and processor. The system can also include an application server, executing on the computer. The application server can include an actor container that manages and provides lifecycle and runtime properties for application classes that are executed as actors in the application server. The actor container can manages a set of event transactions, wherein all storage operations are performed as part of the event transaction that spans each event handler invocation.

Abstract: There is described a crushing plant and a method for controlling the same. The crushing plant involves a gyratory crusher (1) with means for controlling a minimum gap in a crushing chamber, and is driven by a diesel engine (18). A load value is retrieved from the diesel engine e.g. by means of a J1939 interface. If the retrieved value exceeds a predetermined threshold value, the minimum gap is increased. Thereby it can be avoided that the diesel engine stalls; such that continuous operation of the crushing plant may be ensured.

Abstract: In accordance with embodiments, there are provided mechanisms and methods for controlling data flow based on a temporal policy. These mechanisms and methods for controlling data flow based on a temporal policy can enable embodiments to provide a different service level agreement to control network traffic selected from a plurality of service level agreements based upon one or more temporal conditions. The ability of embodiments to provide different service level agreement to control network traffic can enable embodiments to control one or more of access to network resources and traffic flow coordination to enhance efficient usage of the network resources.

Abstract: A network service access gateway is described that provides a pluggable state management architecture for storing state information. The gateway typically processes requests between entities such as external applications and subscriber mobile devices. In processing data, the gateway can implement multiple storage providers which are selected according to the data access requirements of the specific request. Each storage provider can implement a different caching or data management technique in order to provide access to the required information. Examples of the storage providers include in-memory only caches, write-through disk based storage provider, write-behind disk based storage provider and non-cached disk-based storage provider. The particular storage provider can be selected based on a configuration file and according to the traffic path associated with the request.

Abstract: The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.

Abstract: The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.

Abstract: There is described a crushing plant and a method for controlling the same. The crushing plant involves a gyratory crusher (1) with means for controlling a minimum gap in a crushing chamber, and is driven by a diesel engine (18). A load value is retrieved from the diesel engine e.g. by means of a J1939 interface. If the retrieved value exceeds a predetermined threshold value, the minimum gap is increased. Thereby it can be avoided that the diesel engine stalls; such that continuous operation of the crushing plant may be ensured.

Abstract: The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.

Abstract: A network service access gateway is described that provides a pluggable state management architecture for storing state information. The gateway typically processes requests between entities such as external applications and subscriber mobile devices. In processing data, the gateway can implement multiple storage providers which are selected according to the data access requirements of the specific request. Each storage provider can implement a different caching or data management technique in order to provide access to the required information. Examples of the storage providers include in-memory only caches, write-through disk based storage provider, write-behind disk based storage provider and non-cached disk-based storage provider. The particular storage provider can be selected based on a configuration file and according to the traffic path associated with the request.

Abstract: The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial superantigen has been modified to decrease seroreactivity with retained superantigen activity.