Patents by Inventor Goran KUNGULOVSKI

Goran KUNGULOVSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of nucleosomes having multiple-modified histone protein octamers
    Patent number: 10711045
    Abstract: The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer, wherein the artificial protein comprises a first histone modification binding domain of 50 to 200 amino acids binding to a first histone modification, a second histone modification binding domain of 50 to 200 amino acids binding to a second histone modification, a linker of 5 to 50 amino acids connecting the first and the second histone modification binding domain, and an affinity tag. Further disclosed are a nucleic acid encoding the artificial protein, a host cell comprising the nucleic acid and a kit for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer. Further disclosed is an in-vitro method for isolating a nucleosome having a first and a second histone modification.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: July 14, 2020
    Assignee: Universität Stuttgart
    Inventors: Albert Jeltsch, Goran Kungulovski, Rebekka Mauser
  • ISOLATION OF NUCLEOSOMES HAVING MULTIPLE-MODIFIED HISTONE PROTEIN OCTAMERS
    Publication number: 20180066029
    Abstract: The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer, wherein the artificial protein comprises a first histone modification binding domain of 50 to 200 amino acids binding to a first histone modification, a second histone modification binding domain of 50 to 200 amino acids binding to a second histone modification, a linker of 5 to 50 amino acids connecting the first and the second histone modification binding domain, and an affinity tag. Further disclosed are a nucleic acid encoding the artificial protein, a host cell comprising the nucleic acid and a kit for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer. Further disclosed is an in-vitro method for isolating a nucleosome having a first and a second histone modification.
    Type: Application
    Filed: March 15, 2016
    Publication date: March 8, 2018
    Inventors: Albert JELTSCH, Goran KUNGULOVSKI, Rebekka MAUSER