Patents by Inventor Goran Neshich

Goran Neshich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of therapeutic targets for computer-based design of drugs against bacteria containing the PilT protein
    Patent number: 10460827
    Abstract: The present invention relates to a method for identifying target regions existing in the interface of monomers constituting the PilT protein with the view to design molecules potentially applicable in impairing the activity of this protein, thus controlling infectious processes. The method is characterized in (i) selecting at least one amino acid sequence constituting the PilT monomer; (ii) developing a three-dimensional computational model of the PilT homo-hexameric structure; (iii) analyzing and determining, with computer aid, the interface-forming residues (IFR) and their physicochemical and structural characteristics for all the chains of the models of hexameric complexes generated; (iv) selecting the regions to be used as therapeutic targets (and preferred therapeutic targets) in the interface between the monomers based on the intensity of determined parameters; (v) computer-aided design of molecules potentially capable of effecting bindings and/or interactions between target regions of the monomers.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: October 29, 2019
    Assignee: EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA
    Inventors: Goran Neshich, Izabella Agostinho Pena Neshich, Jose Gilberto Jardine, Leticia Nishimura, Ivan Mazoni, José Salim
  • IDENTIFICATION OF THERAPEUTIC TARGETS FOR COMPUTER-BASED DESIGN OF DRUGS AGAINST BACTERIA CONTAINING THE PILT PROTEIN
    Publication number: 20130324425
    Abstract: The present invention relates to a method for identifying target regions existing in the interface of monomers constituting the PiIT protein with the view to design molecules potentially applicable in impairing the activity of this protein, thus controlling infectious processes. The method is characterized in (i) selecting at least one amino acid sequence constituting the PiIT monomer; (ii) developing a three-dimensional computational model of the PiIT homo-hexameric structure; (iii) analyzing and determining, with computer aid, the interface-forming residues (IFR) and their physicochemical and structural characteristics for all the chains of the models of hexameric complexes generated; (iv) selecting the regions to be used as therapeutic targets (and preferred therapeutic targets) in the interface between the monomers based on the intensity of determined parameters; (v) computer-aided design of molecules potentially capable of effecting bindings and/or interactions between target regions of the monomers.
    Type: Application
    Filed: September 8, 2011
    Publication date: December 5, 2013
    Applicant: EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA- EMBRAPA
    Inventors: Goran Neshich, Izabella Agostinho Pena Neshich, Jose Gilberto Jardine, Leticia Nishimura, Ivan Mazoni, Jose Salim