Abstract: A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

Abstract: A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

Abstract: A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.

Abstract: A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.

Abstract: A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.

Abstract: A device, system, and methods are disclosed for detecting the presence or determining a quantitative amount of at least one drug substance from exhaled breath of a subject in-situ. A collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer that comprises at least one SERS-active material. The collecting surface is arranged as an outer surface of a waveguide for contact with exhaled breath, such that at least traces of said at least one drug substance in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum that is detected in-situ for said detecting the presence or determining the quantitative amount of said at least one drug substance from said exhaled breath.

Abstract: An arrangement for determining concentration of substances in a fluid comprising a light source for generating primary light pulses within a wavelength interval, a light pulse splitter adapted to split up the primary light pulses into a predetermined number of secondary light pulses to be transmitted through the fluid, the secondary light pulses being separated in time as well as wavelength to be differently absorbed upon passage of the fluid depending on the concentration of the substances, a detector for detecting intensity of the differently absorbed secondary light pulses, and a comparator for comparing the intensities of the differently absorbed secondary light pulses with different reference intensities corresponding to different substances to thereby determine the concentration of the substances in the fluid.

Abstract: A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

Abstract: A portable system (10) is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit (14) and a housing (12) arranged to hold the sampling unit (14), the sampling unit (14) is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing (12) has at least one inlet (15) for the subject to exhale into the housing (12) to the sampling unit (14) and at least one outlet (16) for the exhaled breath to exit through.

Abstract: A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

Abstract: An arrangement for determining concentration of substances in a fluid comprising a light source for generating primary light pulses within a wavelength interval, a light pulse splitter adapted to split up the primary light pulses into a predetermined number of secondary light pulses to be transmitted through the fluid, the secondary light pulses being separated in time as well as wavelength to be differently absorbed upon passage of the fluid depending on the concentration of the substances, a detector for detecting intensity of the differently absorbed secondary light pulses, and a comparator for comparing the intensities of the differently absorbed secondary light pulses with different reference intensities corresponding to different substances to thereby determine the concentration of the substances in the fluid.

Abstract: An arrangement for determining concentration of substances in a fluid comprising a light source (2) for generating primary light pulses within a wavelength interval, a light pulse splitter (5) adapted to split up the primary light pulses into a predetermined number of secondary light pulses to be transmitted through the fluid, the secondary light pulses being separated in time as well as wavelength to be differently absorbed upon passage of the fluid depending on the concentration of the substances, a detector (13) for detecting intensity of the differently absorbed secondary light pulses, and a comparator (14) for comparing the intensities of the differently absorbed secondary light pulses with different reference intensities corresponding to different substances to thereby determine the concentration of the substances in the fluid.

Abstract: An arrangement for determining concentration of substances in a fluid comprising a light source (2) for generating primary light pulses within a wavelength interval, a light pulse splitter (5) adapted to split up the primary light pulses into a predetermined number of secondary light pulses to be transmitted through the fluid, the secondary light pulses being separated in time as well as wavelength to be differently absorbed upon passage of the fluid depending on the concentration of the substances, a detector (13) for detecting intensity of the differently absorbed secondary light pulses, and a comparator (14) for comparing the intensities of the differently absorbed secondary light pulses with different reference intensities corresponding to different substances to thereby determine the concentration of the substances in the fluid.

Abstract: The present invention is related to a method and device for precision and passive alignment such as precision and passive alignment technology for low cost array fibre access components. A laser carrier is passively aligned to an MT-interface using alignment structures on a replicated carrier. The laser carrier is based on a self-aligned semiconductor laser, flip-chip mounted on a silicon substrate with planar polymeric waveguides.

Abstract: The present invention is related to a method and device for precision and passive alignment such as precision and passive alignment technology for low cost array fibre access components. A laser carrier is passive aligned to an MT-interface using alignment structures on a replicated carrier. The laser carrier is based on a self-aligned semiconductor laser, flip-chip mounted on a silicon substrate with planar polymeric waveguides. The concept for the alignment according to the invention is shown in FIG. 1 as a front view of a laser carrier (1) mounted on a polymeric carrier (5).

Abstract: The present invention is related to a method and device for precision and passive alignment such as precision and passive alignment technology for low cost array fibre access components. A laser carrier is passive aligned to an MT-interface using alignment structures on a replicated carrier. The laser carrier is based on a self-aligned semiconductor laser, flip-chip mounted on a silicon substrate with planar polymeric waveguides. The concept for the alignment according to the invention is shown in FIG. 1 as a front view of a laser carrier (1) mounted on a polymeric carrier (5).

Abstract: Replicated polymeric microstructures have been used in the fabrication of optofiber waveguide connections, with the intention of simplifying the production of such connections, and therewith greatly reduce manufacturing costs. Fabrication is commenced from a silicon chip in which there has been etched grooves whose cross-sectional shape has been adapted to accommodate waveguides, such as optofibers. Firstly, the silicon chip is replicated, by plating the silicon chip with nickel for instance. The replication then serves as a model for producing a plastic copy of the silicon chip. This method of manufacture is able to produce waveguide accommodating grooves (2), such as optofiber accommodating grooves, to a very high degree of accuracy. Furthermore, the method provides a high degree of freedom in the configuration of the grooves, and also enables branched grooves for receiving branched fibres to be produced.

Abstract: The optoelectrical components which up to now have been used in the fibre-optical region have had waveguides of quartz and glass with hermetic encapsulating, which components have had too high manufacturing costs for profitable use. Through making polymeric single mode (SM) waveguides from plastic, for example, benzocyclobutene polymer (BCB) a simple reliable and inexpensive concept for making waveguides can be obtained. Two of the commercially available grades of BCB/DOW Chemicals have furthermore a refractive index difference which permits manufacturing of buried waveguides with SM characteristics. These two types of BCB material have shown themselves to be especially usable for manufacturing of so-called buried SM waveguides: a heat curable grade (1,4) used for under- and over-cladding for waveguides and a photo-definable derivative (3) used as the waveguide material.

Abstract: An encapsulated optocomponent (1) comprises a single-crystal silicon wafer (3) and waveguides (9) located thereon, which at least partly are manufactured by means of process methods taken from the methods for manufacturing electronic integrated circuits. The waveguides (9) extend from an edge of the optoelectronic component (1) to an optoelectronic, active or passive component (11) attached to the surface of the silicon wafer (3). Over the region for connecting the waveguides (9) to the optoelectronic component (11) a transparent plastics material is molded (17), for instance an elastomer, having a refractive index adjusted to improve the optical coupling between the waveguides (9) and the optoelectronic component (11). The molding (17) covers advantageously all of said component (11) to also reduce thermal stresses between it and an exterior, protective layer (19) of a curable plastics material. The molded layer (17) can also cover the whole area of the waveguides (9) to form an upper cladding thereof.

Abstract: An impermeable encapsulated optocomponent and a method for encapsulating an optocomponent includes providing a base, preferably of silicon, supporting waveguides and an optoelectronic component optically coupled to each other. The optoelectronic component is connected to electric driver circuits. Thereafter a silica layer is deposited over a region of the substrate including at least the coupling of the waveguide and optoelectronic component, after which it is encapsulated by applying a layer of curable plastics material. The deposition of silica provides an impermeable inner encapsulation layer and prevents, when applying the curable plastics material, plastics from penetrating between the inner ends of the waveguides and the optoelectronic component, and thus the optical coupling is secured therebetween.