Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.

Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.

Abstract: A method to localize a carrier on a laboratory transport system is presented. The laboratory transport system comprises a carrier associated with an identity, a multi-lane transport module, and a control unit. The carrier comprises a signal transmitter configured to transmit a signal comprising information about the identity. The multi-lane transport module comprises a transport surface comprising a first and a second transport lane as well as a first signal receiver and a second signal receiver each configured to receive the transmitted signal. Based on received signal strengths, the control unit localizes the carrier on one of the transport lanes of the multi-lane transport module.

Abstract: The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.

Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.

Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

Abstract: An instrument and method is provided that conveniently allows rapid amplification of nucleic acids.

Abstract: An instrument and method is provided that conveniently allows rapid amplification of nucleic acids. The instrument comprises in the following order at least one substantially flat temperature sensor element; a heat conducting substrate and a heater layer, whereby the heat conducting substrate comprises one or more channels permeable for fluid.

Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

Abstract: An apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell comprises (a) optionally, an electrical current source; (b) an electromagnet having a winding connected to the current source and an air gap between at least one pair of poles each of which has a corrugated outer surface and (c) a flow-through cell which is configured and dimensioned to receive an amount of magnetic particles to be retained within the flow-through cell and to allow flow of a liquid through the flow-through cell. The liquid carries molecules or particles to be captured by means of the magnetic particles. A portion of the flow-through cell is inserted in air gap.

Abstract: The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).

Abstract: On an analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body, a plurality of receptacles for fluid samples and optics for guiding light beams through the receptacles are arranged. At least part of the optics are designed and/or arranged such that at least part of the light beams is deflected and guided through the receptacles at an angle to the radially outward direction on the disk-like body which means at an angle to the radius, connecting the respective optics with the rotation axis of the disk-like body.

Abstract: Subject of the present invention is a system comprising a cartridge and a device for heating and cooling a mixture in a controlled manner by sensing the temperature of the mixture in said cartridge with at least one sensor element, a device for heating a cartridge comprising a chamber, a method for conducting a thermal profile in a device, and a method for amplifying nucleic acids.