Abstract: Disclosed herein are methods of screening candidate binding compounds to a plurality of target nucleic acids either of the same sequence or of different sequences utilizing a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to various candidate binding compounds. In the presence of a plurality of nucleic acid sequences, the methods described herein also can rapidly determine the specificity of the small molecule or polypeptide to a nucleic acid structure. Also, disclosed herein are methods of measuring binding kinetics of binding compounds to a target nucleic acid using a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to varying concentrations of the candidate binding compound.

Abstract: A flow transmitter method and system involves obtaining, via a flow sensor, sensor measurements of flow characteristics of a moving medium; outputting, via a processor, a drive signal for driving a pulse output circuit to generate a pulse signal according to the sensor measurements from the sensor; and generating, via a switching circuit of a pulse output circuit, a pulse signal according to the drive signal. The method and system further involve monitoring, via a diagnostic circuit connected to the switching circuit, current corresponding to the pulse signal; and determining, via the processor, whether the output circuit is operating in a normal or abnormal state based on the drive signal from the processor and a feedback signal corresponding to the monitored current from the diagnostic circuit.

Abstract: A flow transmitter method and system involves obtaining, via a flow sensor, sensor measurements of flow characteristics of a moving medium; outputting, via a processor, a drive signal for driving a pulse output circuit to generate a pulse signal according to the sensor measurements from the sensor; and generating, via a switching circuit of a pulse output circuit, a pulse signal according to the drive signal. The method and system further involve monitoring, via a diagnostic circuit connected to the switching circuit, current corresponding to the pulse signal; and determining, via the processor, whether the output circuit is operating in a normal or abnormal state based on the drive signal from the processor and a feedback signal corresponding to the monitored current from the diagnostic circuit.

Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

Abstract: The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

Abstract: Various governmental agencies each utilize one of four currently available radio frequency bands to facilitate intra-agency communications. Each of the radio frequency bands includes a mutual-aid channel. In the practice of the present invention whenever a state of emergency involving a particular agency is determined, the agency is directed to tune its radio communication system to the mutual-aid channel within the radio frequency band utilized by the agency. The mutual-aid channels of all of the radio frequency bands are interconnected during the state of emergency thereby facilitating communication among all of the agencies that are affected by the emergency.

Abstract: A low power analog output circuit is disclosed that utilizes a low pass filter driven by a bit stream to render a waveshaped output signal based upon a raw digital data signal. The analog output circuit includes sequential bit pattern selection logic that receives as an input, the raw digital data signal. The analog output circuit also includes a bit pattern storage that specifies bit stream sequences that are selected in accordance with control signals generated by the state machine based upon its current state and the current raw digital data signal. The analog output circuit includes an output stage driven by a digital input signal corresponding to values provided by a bit stream sequence selected from the bit pattern storage. The output stage comprises a low pass filter circuit having an effective time constant that is greater than a hold period associated with a single bit of the bit stream sequence that drives the digital input signal.

Abstract: Various governmental agencies each utilize one of four currently available radio frequency bands to facilitate intra-agency communications. Each of the radio frequency bands includes a mutual-aid channel. In the practice of the present invention whenever a state of emergency involving a particular agency is determined, the agency is directed to tune its radio communication system to the mutual-aid channel within the radio frequency band utilized by the agency. The mutual-aid channels of all of the radio frequency bands are interconnected during the state of emergency thereby facilitating communication among all of the agencies that are affected by the emergency.

Abstract: An indirect clamping topology may be used to protect against the damaging effects of an electrostatic discharge event. An input node of a device is protected by a guard. The guard is driven by a signal from a unity-gain amplifier that flows through a resistance. The input node is clamped to the guard by a diode, and the guard is clamped to a low-impedance rail by another diode. The resistance of the low-impedance rail is less than that of the resistance through which the signal from the unity-gain amplifier flows, so that voltage resulting from the event flows to the low-impedance rail and not to the amplifier.

Abstract: A method of monitoring/controlling Thysanoptera (hereafter thrips) by the use of a behaviour modifying compound of Formula 1, wherein Formula 1 is:- where R1 is a C8-C12 group and R2 is a C2-C8 group.

Abstract: Compositions, methods and apparatus provide for the control of Ixodid hard tick populations. The compositions comprise a cholesteryl ester and 2,6-dichlorophenol. In combination, these compounds attract and induce mating behavior in male ticks thus disrupting normal mating, with subsequent reduction in tick populations.

Abstract: A self-locking, reclosable carton includes a rectangular floor panel and rectangular side wall panels extending vertically from opposite side edges of the floor panel. Each of the side wall panels includes two inner edge panels which are folded inwardly at the ends of the floor panel. The floor panel has outer end panels which are locked in slightly spaced relationship to the inner end panels by means of tab members which can be forced through narrow openings at the edges of the inner end panels. A cover assembly inclues cover panels extending inwardly from the upper edges of the side wall panels. Each of the cover panels includes cover flaps at the ends which can be inserted into the space between the outer end panel and the inner end panels and held there by frictional engagement to keep the carton closed.

Abstract: In a two piece box having a base tray with a bottom panel, side walls and end walls and an attaching lid, the improvement comprising at least one slot in each said end wall, at least one recess in the upper edge of each of said side walls, and a generally rectangular lid comprising at least one extension finger projecting from each end of said lid for insertion in a corresponding one of said slots in said end walls of said base tray, and at least one T-shaped projection extending horizontally from each side of said lid for insertion in a corresponding one of said recesses in each said side wall of said base tray whereby said lid is removably locked in place in said base tray.

Abstract: A rectangular, tube like carton having four upstanding sidewalls, a base portion, and a top closure includes an improved reclosable pour spout. The top closure and spout include a pair of contiguous, triangular shaped segments which form portions of the top closure, each segment having one edge thereof extending along one half the width of a first sidewall of the carton. A second edge of each of the triangular shaped segments extends along the longitudinal axis of the top closure. The third edge of each triangular segment is hingedly connected to the top closure. An insertable tab member is hingedly attached to the one sidewall of the carton, the insertable tab being generally triangular in configuration. The top closure and spout further include two minor tabs, each being hingedly connected intermediate the insertable tab and one of the triangular shaped segments.

Abstract: A Tank fire control system is disclosed which includes a sighting device having a visual display on which a plurality of images are presented in superimposition. The first image is formed from radiation in the visible spectrum emanating from the field view, a second image is defined by a target aiming mark and a third image is formed from radiation in the infrared spectrum emanating from the same field of view and the field of view is adjustable by operator action.