Patents by Inventor Gordon Bruton

Gordon Bruton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists
    Patent number: 8492375
    Abstract: The present invention relates to novel diazepanyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: July 23, 2013
    Assignee: Glaxo Group Limited
    Inventors: Gordon Bruton, Anthony Huxley, Barry Sidney Orlek, Kishore Kalidas Rana
  • 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS
    Publication number: 20110039833
    Abstract: The present invention relates to novel diazepanyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: October 26, 2010
    Publication date: February 17, 2011
    Inventors: GORDON BRUTON, Anthony Huxley, Barry Sidney Orlek, Kishore Kalidas Rana
  • 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists
    Patent number: 7846922
    Abstract: The present invention relates to novel diazepanyl derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: December 7, 2010
    Assignee: Glaxo Group Limited
    Inventors: Gordon Bruton, Anthony Huxley, Barry Sidney Orlek, Kishore Kalidas Rana
  • USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME
    Publication number: 20100041672
    Abstract: The use of 5-HT6 serotonin receptor antagonists of formula (I): or pharmaceutically acceptable salts thereof, is described for the treatment of Irritable Bowel Syndrome and pain in mammals, more particularly inflammatory, neuropathic or visceral pain.
    Type: Application
    Filed: March 19, 2008
    Publication date: February 18, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Gordon Bruton, Barry Sidney Orlek, Geoffrey Stemp
  • Methylene dipiperidine derivatives
    Patent number: 7638631
    Abstract: The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: December 29, 2009
    Assignee: Glaxo Group Limited
    Inventors: Gordon Bruton, Vicky Johnstone, Barry Sidney Orlek
  • Piperazine derivates and their use for the treatment of neurological and psychiatric diseases
    Patent number: 7592347
    Abstract: The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: September 22, 2009
    Assignee: Glaxo Group Limited
    Inventors: Gordon Bruton, Barry Sidney Orlek, Kishore Kalidas Rana
  • Methylene Dipiperidine Derivatives
    Publication number: 20080108624
    Abstract: The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: September 16, 2005
    Publication date: May 8, 2008
    Applicant: GLAXO GROUP LIMITED
    Inventors: Gordon Bruton, Vicky Johnstone, Barry Sidney Orlek
  • 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists
    Publication number: 20080045505
    Abstract: The present invention relates to novel diazepanyl derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: October 14, 2004
    Publication date: February 21, 2008
    Inventors: Gordon Bruton, Anthony Huxley, Barry Sidney Orlek, Kishore Kalidas Rana
  • Pyrrolidine Derivatives as Histamine Receptors Ligands
    Publication number: 20080045506
    Abstract: The present invention relates to pyrrolidine derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: October 13, 2005
    Publication date: February 21, 2008
    Applicant: GLAXO GROUP LIMITED
    Inventors: Gordon Bruton, Ian Cooper, Barry Orlek
  • Piperazine derivates and their use for the treatment of neurological and psychiatric diseases
    Publication number: 20070054917
    Abstract: The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: April 21, 2004
    Publication date: March 8, 2007
    Inventors: Gordon Bruton, Barry Orlek, Kishore Rana
  • Sulphonyl hydroxamic acid derivatives as inhibitors of s-cd23
    Publication number: 20060247271
    Abstract: Compounds of formula (I): wherein R is hydrogen, alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23.
    Type: Application
    Filed: January 30, 2004
    Publication date: November 2, 2006
    Inventor: Gordon Bruton
  • Substituted piperidines as histamine h3 receptor ligands
    Publication number: 20060247227
    Abstract: The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: July 16, 2004
    Publication date: November 2, 2006
    Inventors: James Bailey, Gordon Bruton, Anthony Huxley, Peter Milner, Barry Orlek
  • Quinoline derivatives, process for preparing them and use for the treatment of diseases mediated by s-CD23
    Patent number: 7045626
    Abstract: A compound of formula (I): useful in the treatment and prophylaxis of conditions mediated by s-CD23
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: May 16, 2006
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Desmond John Best, Gordon Bruton, Barry Sidney Orlek
  • Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies
    Patent number: 7038055
    Abstract: A compound of formula (I) useful in the treatment and prophylaxis of conditions mediated by s-CD23
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: May 2, 2006
    Assignee: SmithKlineBeecham plc
    Inventors: Desmond John Best, Gordon Bruton, Barry Sidney Orlek
  • Aryloxyalkylamine derivatives as h3 receptor ligands
    Publication number: 20060052597
    Abstract: The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
    Type: Application
    Filed: October 20, 2003
    Publication date: March 9, 2006
    Inventors: Desmond Best, Gordon Bruton, Thomas Heightman, Barry Orlek
  • Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides
    Publication number: 20050288376
    Abstract: Compounds of formula (I): R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl, are useful in the treatment and prophylaxis of conditions mediated by s-CD23.
    Type: Application
    Filed: August 16, 2005
    Publication date: December 29, 2005
    Inventors: Desmond Best, Gordon Bruton, Barry Orlek, Kishore Rana, Graham Walker
  • Quinoline derivatives, process for preparing them and use for the treatment of diseases mediated by s-cd23
    Publication number: 20050085505
    Abstract: A compound of formula (I): useful in the treatment and prophylaxis of conditions mediated by s-CD23
    Type: Application
    Filed: November 25, 2002
    Publication date: April 21, 2005
    Inventors: Desmond Best, Gordon Bruton, Barry Orlek
  • Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies
    Publication number: 20050070572
    Abstract: A compound of formula (I) useful in the treatment and prophylaxis of conditions mediated by s-CD23.
    Type: Application
    Filed: November 25, 2002
    Publication date: March 31, 2005
    Inventors: Desmond Best, Gordon Bruton, Barry Orlek
  • (Hetero) bicyclymethanesulfonylamino-substituted hydroxamic acid derivates
    Publication number: 20040225006
    Abstract: Compounds of formula (I) wherein R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF.
    Type: Application
    Filed: May 14, 2004
    Publication date: November 11, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Gordon Bruton, Andrew Faller, Barry Sidney Orlek, Kishore Kalidas Rana, Graham Walker
  • Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides
    Publication number: 20040024066
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: June 9, 2003
    Publication date: February 5, 2004
    Inventors: Desmond John Best, Gordon Bruton, Barry Sidney Orlek, Kishore Rana, Graham Walker