Abstract: Fumonisins are a type of mycotoxin that contaminate different products, for example, feed and food products, including corn-based products, which can lead to serious health risks to humans and livestock. Current methods for detoxifying fumonisin-contaminated products are complex and expensive. The present disclosure provides a recombinant microbial host cell expressing an heterologous polypeptide having fumonisin amine oxidase activity, the recombinant microbial host cell comprising an heterologous nucleic acid molecule encoding the heterologous polypeptide having fumonisin amine oxidase activity, a variant thereof or a fragment thereof. The heterologous polypeptide having fumonisin amine oxidase activity can be used to detoxify a fumonisin mycotoxin present in feed and food products, for example from grains and products derived from grains.

Abstract: A system for managing product inventory includes an Internet-connected server and software executing on the server from a non-transitory physical medium, the software providing establishment of a first association of at least one stock keeping unit (SKU) and any associated metadata including product availability counts to at least one point in time and or at least one time range identified within an interactive shopping media presentation, establishment of a second association of at least one potential consumer to the interactive shopping media presentation, monitoring for and tracking of interaction sequences initiated by the at least one potential consumer, the interaction sequences enabled from within the interactive shopping media presentation or from within an interactive display associated thereto, and adjustment of the SKU-based product availability counts in the SKU metadata relative to the latest interaction results.

Abstract: The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.

Abstract: The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.

Abstract: A system for shopping includes, an Internet-connected server, and software executing on the server from a non-transitory physical medium, the software providing a first function for embedding, upon request, a machine-readable code into the source code of a remote webpage, the machine-readable code specifying a link to video player software and a link to at least one digital video file, and a second function for establishing at least one bidirectional communication session between a remote appliance connected to the webpage and a host server.

Abstract: A system for managing product inventory includes an Internet-connected server and software executing on the server from a non-transitory physical medium, the software providing establishment of a first association of at least one stock keeping unit (SKU) and any associated metadata including product availability counts to at least one point in time and or at least one time range identified within an interactive shopping media presentation, establishment of a second association of at least one potential consumer to the interactive shopping media presentation, monitoring for and tracking of interaction sequences initiated by the at least one potential consumer, the interaction sequences enabled from within the interactive shopping media presentation or from within an interactive display associated thereto, and adjustment of the SKU-based product availability counts in the SKU metadata relative to the latest interaction results.

Abstract: The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.

Abstract: The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.

Abstract: A mounting flange of a thermostat having a seat member including a hard seat and the mounting flange for clamping the thermostat in a counterbore of a thermostat housing has an axial dimension which is less than or equal to the axial dimension of the counterbore. An elastomeric sealing element is interposed between the mounting flange and at least one of the thermostat housing and an engine on which the thermostat housing is mounted.