Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

Abstract: Disclosed are methods, systems, devices, apparatus, media, design structures, and other implementations, including a method for crest factor reduction (CFR) processing that includes receiving a first complex-valued sample of a signal for radio transmission, determining a resultant clipped complex-valued sample for the first complex-valued sample, resulting from projection of a second complex-valued sample, associated with the first complex-valued sample, into a selected one of a plurality of different tangent lines that are tangential to a circle representation with a radius h in a complex-valued plane, and processing the signal using the determined clipped complex-valued sample to produce a resultant CFR signal.

Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—GY-AFSSS (SEQ ID No. 1); CDR2—YPGDED (SEQ ID No. 2) CDR3—SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—SASSSVSYMH (SEQ ID No. 4); CDR2—DTSKLAS (SEQ ID No. 5) CDR3—QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

Abstract: A mortar ammunition round which contains at least three fragment producing regions covered by a threadably removable aluminum cowling. Detachment of the cowling provides access to several of the fragment producing regions which are located on a removable cup device. A different cup device may then be selectively inserted and the cowling replaced, forming a new mortar round of different select performance capabilities.

Abstract: Switching interference is a primary artifact which affects the accuracy of arc detectors. To address switching interference, conventional arc detectors employ computationally intensive techniques which are often designed specifically for a target application. Thus, conventional arc detectors require a significant amount of hardware to accurately detect arc faults, which can increase costs of the power systems and prohibit wide deployment of arc detectors. With improved signal processing, a unique method for arc detection can accurately detect arc faults efficiently while tolerate switching interference from an inverter of the power system. Specifically, the method provides accurate but efficient arc detection by using a small Fast Fourier Transform with coherent sampling that is accomplished with a common clock generator in combination with signal conditioning. The overall system implementing the method is also programmable to suit a variety of target applications.

Abstract: There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1-GY-AFSSS (SEQ ID No. 1); CDR2-YPGDED (SEQ ID No. 2) CDR3-SLLYGDYLDY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1-SASSSVSYMH (SEQ ID No. 4); CDR2-DTSKLAS (SEQ ID No. 5) CDR3-QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.

Abstract: In safety-critical computer systems, fault tolerance is an important design requirement. Data buses for on-chip interconnection in these processor-based systems are exposed to risk arising from faults in the interconnect itself or in any of the connected peripherals. To provide sufficient fault tolerance, a safety node is inserted between an upstream master section and a downstream slave section of an on-chip bus hierarchy or network. The safety node provides a programmable timeout monitor for detecting a timeout condition for a transaction. If timeout has occurred, the safety node transmits a dummy response back to the master, assumes the role of a master, and waits for the slave device to respond. Furthermore, the safety node rejects any subsequent requests by any of the masters on the upstream section by transmitting a dummy response to those subsequent requests, thus enabling these masters to avoid deadlock or stall.

Abstract: Switching interference is a primary artifact which affects the accuracy of arc detectors. To address switching interference, conventional arc detectors employ computationally intensive techniques which are often designed specifically for a target application. Thus, conventional arc detectors require a significant amount of hardware to accurately detect arc faults, which can increase costs of the power systems and prohibit wide deployment of arc detectors. With improved signal processing, a unique method for arc detection can accurately detect arc faults efficiently while tolerate switching interference from an inverter of the power system. Specifically, the method provides accurate but efficient arc detection by using a small Fast Fourier Transform with coherent sampling that is accomplished with a common clock generator in combination with signal conditioning. The overall system implementing the method is also programmable to suit a variety of target applications.

Abstract: In safety-critical computer systems, fault tolerance is an important design requirement. Data buses for on-chip interconnection in these processor-based systems are exposed to risk arising from faults in the interconnect itself or in any of the connected peripherals. To provide sufficient fault tolerance, a safety node is inserted between an upstream master section and a downstream slave section of an on-chip bus hierarchy or network. The safety node provides a programmable timeout monitor for detecting a timeout condition for a transaction. If timeout has occurred, the safety node transmits a dummy response back to the master, assumes the role of a master, and waits for the slave device to respond. Furthermore, the safety node rejects any subsequent requests by any of the masters on the upstream section by transmitting a dummy response to those subsequent requests, thus enabling these masters to avoid deadlock or stall.

Abstract: A practice projectile allows for the release of flame or smoke and bang upon impact to simulate a successful deployment of the tactical cartridge. The practice projectile includes three main components: a center vent tube, a plurality of vent holes, and a plurality of vent plugs. The center vent tube compensates for the physical properties of the tactical mortar cartridge and provides a passage for an efficient release of smoke upon a fuze function. The vent holes are positioned at the rear end of the projectile body to sufficiently release pressure, flame and smoke upon a fuze function. The vent plugs seal the vent holes to protect the interior of the projectile during storage, handling, and launching.