Abstract: A medical ventilator tube and manifold assembly. The assembly is used to connect between a patient breathing tube and a medical ventilator machine used in providing assistance to a patient for breathing. The tube and manifold assembly provides a quick-change patient ventilator circuit which allows a plurality of tubing connections to be disconnected and reconnected simultaneously so that a portion of the ventilator circuit may be removed for sterilization and quickly replaced, thus minimizing danger to the patient. The ventilator circuit includes a ventilator machine manifold and a circuit manifold connectable to the ventilator machine manifold. A latch is provided for securely holding the manifolds together. The necessary tubing connections are made between the patient breathing tube and the circuit manifold and between the medical ventilator and the ventilator machine manifold. The manifolds have a plurality of sealingly separated passageways therethrough which are connected to the corresponding tubing.