Abstract: The invention concerns method of treating multiple sclerosis (MS) by administering a therapeutically effective dose of LOU064 or a pharmaceutically acceptable salt thereof.

Abstract: The invention concerns ofatumumab for use in the treatment or prevention of pediatric multiple sclerosis (MS). According to the invention, ofatumumab is administered during a loading dose regimen at weeks 0, 1, 2 of the dosage regimen; and ofatumumab is administered during a maintenance dose regimen starting at week eight of the dosage regimen and continuing thereafter every six weeks.

Abstract: Disclosed is a system for monitoring and control of machinery. In embodiments, a maintenance sensor measures data from a machine and processes the data prior to its wireless transmission to a wireless zone kit, which, in turn, sends the data to a controller. Processing of measured data at a wireless maintenance sensor can include generating a digital energy model, that provides sufficient data to the control system to allow decisions and actions to be taken by an operator, while reducing power consumption and extending a lifetime of the sensor and/or a power source of the sensor. The processing elements may include Fourier analysis of the data. A method of operation of a system for monitoring and controlling a machine is also disclosed.

Abstract: One illustrative embodiment includes an apparatus for detecting if a fastener moves from a first position to a different second position. The apparatus includes a first connector for connecting a first side of a contact bridge to the fastener for movement in response to movement of the fastener, and a second connector for connecting a second side of the contact bridge to an object to remain stationary relative to the object. One of the first and second sides of the contact bridge includes first and second spaced apart electrical conductors; the other side includes a third electrical conductor. The third electrical conductor is positionable to contact the first and second electrical conductors when the fastener is in the first position, and the third electrical conductor may be spaced apart from at least one of the first and second electrical conductors when the fastener is in the second position.

Abstract: One illustrative embodiment includes an apparatus for detecting if a fastener moves from a first position to a different second position. The apparatus includes a first connector for connecting a first side of a contact bridge to the fastener for movement in response to movement of the fastener, and a second connector for connecting a second side of the contact bridge to an object to remain stationary relative to the object. One of the first and second sides of the contact bridge includes first and second spaced apart electrical conductors; the other side includes a third electrical conductor. The third electrical conductor is positionable to contact the first and second electrical conductors when the fastener is in the first position, and the third electrical conductor may be spaced apart from at least one of the first and second electrical conductors when the fastener is in the second position.

Abstract: An articulating assembly of or for an adjustable hinge assembly, the articulating assembly comprising or including a height control arm supporting a mounting element at its distal end and pivotable about its proximal end for height adjustment, a convex member or members (“member(s)”) at or adjacent the distal region of the height control arm defining a distinct or merged pair of convex surfaces, the convex member(s) having a passageway therethrough, a pair of concave members engaged with the convex surfaces of the convex member(s) in a cupping manner, the concave members each having a passageway therethrough, and a pin located through the aligned passageways of the convex member(s) and concave members, the pin also being engaged with the mounting element to couple the mounting element to the height control arm, wherein the pin is dimensioned such that there is a clearance with respect to the passageway of the convex member(s) to allow at least limited articulating movement of the mounting element relative to

Abstract: The invention relates to new reactive mesogenic compounds (RM), polymerisable liquid crystal (LC) mixtures and polymers comprising them, and the use of the compounds, mixtures and polymers in optical, electrooptical, electronic, semiconducting or luminescent components or devices, in decorative, security or cosmetic applications, especially for use in polymer films having high optical dispersion.

Abstract: One illustrative embodiment includes an apparatus for detecting if a fastener moves from a first position to a different second position. The apparatus includes a first connector for connecting a first side of a contact bridge to the fastener for movement in response to movement of the fastener, and a second connector for connecting a second side of the contact bridge to an object to remain stationary relative to the object. One of the first and second sides of the contact bridge includes first and second spaced apart electrical conductors; the other side includes a third electrical conductor. The third electrical conductor is positionable to contact the first and second electrical conductors when the fastener is in the first position, and the third electrical conductor may be spaced apart from at least one of the first and second electrical conductors when the fastener is in the second position.

Abstract: The invention relates to new reactive mesogenic compounds (RM), polymerisable liquid crystal (LC) mixtures and polymers comprising them, and the use of the compounds, mixtures and polymers in optical, electrooptical, electronic, semiconducting or luminescent components or devices, in decorative, security or cosmetic applications, especially for use in polymer films having high optical dispersion.

Abstract: The invention relates to a liquid crystal (LC) material that aligns homeotropically on substrates with high or low surface energy.

Abstract: A sole for a shoe with a foot guiding mechanism which has the particularity that the sole comprises a sole body which has, on an outer face thereof, at least one protrusion. The at least one protrusion is flexible in order to produce a desired movement of the protrusion which is suitable to force a guided sequence for a foot, wearing the shoe sole, from when the heel section initially contacts a ground surface to when the front edge of the sole breaks contact with the ground surface.

Abstract: A sole assembly for a shoe. The sole assembly comprises an exterior sole for engaging with a ground surface with the exterior sole having an upwardly facing surface. A foot bed having an undersurface, facing the upwardly facing surface of the exterior sole, and an upwardly facing surface for supporting a foot of a wearer. At least one lug is secured to the undersurface of the foot bed to space the undersurface from the upwardly facing surface of the exterior sole.

Abstract: The invention relates to a negative birefringent retardation film comprising polymerised liquid crystal (LC) material with helically twisted structure and planar orientation, its use in compensators and electrooptical displays like liquid crystal displays, and to compensators and liquid crystal displays comprising such a negative retardation film.

Abstract: The invention relates to a liquid crystal (LC) material that aligns homeotropically on substrates with high or low surface energy.

Abstract: A footwear sole structure for dynamically directing interacting forces between a user's foot and the footwear during a stride, including an inner sole located adjacent the user's foot, a mid-sole located between the inner sole and the footwear, and a rib ribbon force transfer structure located between the inner sole and the mid-sole wherein the rib ribbon includes a plurality of ribs spaced along and transversely to a spine axis and attached to a longitudinally extending spine. The rib ribbon resists flexing about an axis parallel to the spine axis and allows a relatively greater degree of flexing about an axis transverse to the spine axis and the rib ribbon is located along a path between the inner and mid-soles to dynamically direct the interacting forces between a user's foot and the footwear as the user's weight shifts from a heel to a toe position during a stride.

Abstract: A sole for a shoe with a foot guiding mechanism which has the particularity that the sole comprises a sole body which has, on an outer face thereof, at least one protrusion. The at least one protrusion is flexible in order to produce a desired movement of the protrusion which is suitable to force a guided sequence for a foot, wearing the shoe sole, from when the heel section initially contacts a ground surface to when the front edge of the sole breaks contact with the ground surface.

Abstract: The invention relates to a process of preparing films and multilayers comprising polymerized liquid crystal material with uniform orientation, to films and multilayers obtained by said process and their use for optical and electrooptical applications.

Abstract: A birefringent film comprising at least one birefringent layer of liquid crystal material forming multi domains with a splayed structure may be coated onto a reflective substrate, e.g., with an aluminium surface. The birefringent film is particularly suited for decorative, security, authentification or identification applications.

Abstract: The invention relates to a process of preparing films and multilayers comprising polymerized liquid crystal material with uniform orientation, to films and multilayers obtained by said process and their use for optical and electrooptical applications.