Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: The invention provides a handheld, manually operable fluid applicator, particularly suited to the needs of surgeons, for dispensing a multi-component fluid applicator, for example fibrin and thrombin components of a tissue adhesive. A preferred applicator has a body containing reservoirs for the sealants and a detachable dispensing head which can be removed to refill the reservoirs. In the mixing head, the sealant components undergo turbulent mixing, for mixing efficacy, in a mixing chamber provided in a one-piece flexible and resilient manifold have “self-sealing” inlet and outlet ports. To enhance mixing, the mixing chamber has an increased cross-sectional area over the combined areas of the component supply passages and the fluid flows are directly opposed to impinge on each other in the mixing chamber. The applicator body and mixing head each have a housing with an ergonomic, streamlined or otherwise smoothly contoured shape and esthetic appearance.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

Abstract: A device for retrieving clot material and distal protection within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member having proximal and distal extremities is carried by the distal extremity of the elongated tubular member and is movable between radially contracted and expanded configurations. A deformable membrane at least partially covers the expansile member in the radially expanded configuration. A guide member is coupled to the distal extremity of the expansile member and has proximal and distal ends. A handle assembly is carried by the proximal extremity of the elongated tubular member for moving said expansile member between radially contracted and expanded configurations. The handle assembly is detachable from the proximal extremity of the elongated tubular member.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment tool is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment tools.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: A spray applicator particularly suited to needs of surgeons for dispensing a multi-component fluid, for example fibrin and thrombin components of a tissue adhesive. The spray applicator having a spray nozzle, a liquid dispensing aperture, a spray plate to be impacted by the liquid dispensed and a gas nozzle to provide a stream of carrier gas to carry the dispensed liquid away from the spray plate to form a spray.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane at least partially covers the expansile member and is sized so as to be capable of expanding as the expansile member moves from the contracted configuration to the expanded configuration. Deployment members are carried by the proximal extremity of the elongated tubular member and are coupled to the expansile member. The deployment members are adapted to be capable of moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to the deployment members.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. A first elongate tubular member has proximal and distal extremities and has a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member is and movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member, and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. A deployment mechanism is carried by the proximal extremity of the first elongate tubular member and is adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions. A deployment mechanism includes a push-pull wire with proximal and distal extremities and extends through the first elongate tubular member and is coupled to the expansile member.

Abstract: A biological sealant comprising a gelatin slurry. The slurry contains gelatin, saline or water and thrombin.

Abstract: A device for introducing and polymerizing polymeric biomaterials in the human body. The device has a first elongate tubular member having proximal and distal extremities and a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member and is movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. A second elongate tubular member has proximal and distal extremities, a longitudinal axis and a first lumen extending from the proximal to the distal extremity of the second elongate tubular member. The distal extremity of said second elongate tubular member terminates proximal to the distal extremity of said first elongate tubular member and adjacent to said expansile member.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. A first elongate tubular member has proximal and distal extremities and has a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member and is movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. A deployment mechanism is carried by the proximal extremity of the first elongate tubular member and is adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions. A biological sealant introducer is connected to the first elongate tubular member for introducing a biological sealant into the body proximal to the expansile member and external to the lumen of the vessel.

Abstract: A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises a first elongate tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the first elongate tubular member and is movable between contracted and expanded positions. The expansile member has a predetermined configuration in the expanded position. A deformable membrane covers the expansile member and is sized so as to be capable of overlying and underlying the expansile member in the expanded position. Deployment means are carried by the proximal extremity of the first elongate tubular member and are adapted to be operated by the human hand for controlling movement of the expansile member between the contracted and expanded positions.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: A closure device for percutaneously forming a closure of a puncture in the tissue of human body. The device comprises a flexible elongate tubular member having proximal and distal extremities and a longitudinal axis. The flexible elongate tubular member has a first lumen extending from the proximal extremity to the distal extremity. A closure assembly is carried by the distal extremity of the flexible elongate tubular member and is movable between contracted and expanded positions. The closure assembly includes a closure mechanism covered by an impermeable membrane. A handle is carried by the proximal extremity of the flexible elongate tubular member and is adapted to be grasped by the human hand. A deployment mechanism is carried by the handle and extends through the flexible elongate tubular member and is coupled to the closure assembly for moving the closure assembly from the contracted position to the expanded position.