Abstract: The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that the nucleic acid can be directly detected when bound by fluorescently labeled compound; and directly detecting the location of fluorescence within the cell, fluorescence aggregated at the site of the nucleic acid array indicating a compound that binds to the selected nucleic acid. In particular compounds such a transcription factors can be screened. Reagents for such method are provided including a mammalian cell having a plurality of steroid receptor response elements in an array such that the response element can be directly detected when bound by fluorescently labeled steroid receptor and a chimeric protein comprising a fluorescent protein fused to a steroid receptor.

Abstract: An HBr laser is pumped by a slave laser power oscillator which excites the (2,0) absorption band of the HBr laser, to cause it to lase around four microns. A tunable master oscillator, which is frequency locked to an HBr reference cell, seeds the slave oscillator and maintains lock-on to an absorption line in the (2,0) band of HBr.