Abstract: The Specification describes a method of systemically treating immunological disorders or inflammatory disorders having a significant immunological component which comprises administering to a subject suffering from such a disorder an initial dosage in the case of a human adult subject of 50 to 500 mg of from more than betamethasone 21-adamantane-1'-carboxylate, dexamethasone 21-adamantane-1'-carboxylate or a corresponding 11-ketone, or in the case of other subjects, an equivalent dosage calculated on the body weight of the subject. The Specification further describes pharmaceutical and veterinary compositions for use in the above method, each dosage unit containing 50 to 500 mg of the 21-adamantane-1'-carboxylate steroid.

Abstract: Anaesthetic steroids of the androstane and 19-norandrostane series are described, the steroids possessing a 3.alpha.-hydroxy group, a 17.alpha.-hydrogen atom and at the 17.beta.-position a --COSH or esterified --COSH group.

Abstract: Steroid anaesthetics of the pregnane and 19-norpregnane series are described, the steroids having a 3.alpha.-hydroxy group, a 17.alpha.-hydrogen atom, a 20-oxo group and at the 21-position a cyano, azido or basic amino group.

Abstract: Process for preparing 9 .alpha.-hydroxy-11 .beta.-nitro-oxysteroids having a aromatic ring A wherein an aromatic A-ring-containing 9, 11-unsubstituted steroid or corresponding 9,11-dehydrosteroid is oxidized with ceric ions in the presence of nitrate ions.

Abstract: The invention provides 3.alpha.-oxygenated pregnane 21-ethers possessing a hydroxy group in the 3.alpha.-position; a hydrogen atom or a methyl group at the 10-position; a hydrogen atom in the 17.alpha.-position; a keto group in the 20-position; and an etherified hydroxyl group in the 21-position.

Abstract: Steroid anaesthetics of the pregnane and 19-norpregnane series are described, the compounds possessing a 3.alpha.-hydroxy group, a 17.alpha.-hydrogen atom, a 20-oxo group and at the 21-position the residue of a sulphur nucleophile or a sulphone or sulphoxide grouping.

Abstract: Steroids of the androstane and pregnane series possessing a 2.alpha.-hydrogen or halogen or an alkyl group; a 3.alpha.-hydroxy or acyloxy group, a 3.beta.-hydrogen or alkyl group; an 11.beta.-hydrogen or hydroxy group or an epoxy group linked also to the 9-position; an 11.alpha.-hydrogen or alkyl or allyl group; or an 11-oxo group; a 16 hydrogen or halogen or a methyl or dimethyl group; a 20-oxo or ethylenedioxy group; and a 20-methyl or alkoxy group. The compounds may be unsaturated at the 1(2), 8(9) or 9(11) positions.The compounds possess anaesthetic properties.

Abstract: This invention relates to steroids of the pregnane and 19-norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2.beta.-position, a 3.alpha.-hydroxy group and a 5.alpha.-hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steroids is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2.alpha.,3.alpha.-epoxy-pregnane or 19-norpregnane with a reagent which introduces the desired 2.beta.-substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention.

Abstract: Steroids of the androstane series having a 3.alpha.-hydroxy group, a 3.beta.-hydrogen or methyl group; a 10-hydrogen atom or methyl group, an 11-oxo group or two hydrogen atoms at the 11-position, a 17.alpha.-hydrogen atom, and a group at the 17.beta.-position which is esterified carboxyl group, an N-mono or di-substituted carbamoyl group, a cyano group, a formyl group or an acetalised formyl group; and the 3.alpha.-esters thereof.The steroids possess anaesthetic properties.

Abstract: 11.beta.-Halo-9.alpha.,12-unsubstituted-C.sub.19 -steroids having hormonal activity and a process for preparing same by reacting the corresponding 11.alpha.-hydroxy steroid with a compound of the formula ##EQU1## where R.sup.1 and R.sup.2 are alkyl groups having 1-8 carbon atoms or aralkyl or aryl groups or, together with the nitrogen atom to which they are attached, comprise a heterocyclic radical;R.sup.3 and R.sup.4 are chlorine, bromine or fluorince atoms or a fluorine atom together with a chlorine or bromine atom and R.sup.5 is hydrogen or R.sup.4 and R.sup.5 together represent a carbon-carbon bond;R.sup.6 is a chlorine, bromine or fluorine atom andR.sup.7 is a chlorine, bromine or fluorine atom or a trifluoromethyl group, the reaction being effected in the presence of chloride or bromide ions when neither R.sup.3 nor R.sup.4 is chlorine or bromine.