Patents by Inventor Gordon J. Rafool

Gordon J. Rafool has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for inhibiting reverse transcript of a retrovirus
    Patent number: 6319711
    Abstract: An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiretroviral to the infected system, wherein the reverse transcription process is inhibited via steric hindrance, halting the viral RNA replication. Delivery may be accomplished by conventional methods, such as via oral dosing or injection. Additional delivery methods are also contemplated, including packaging in liposomes and protein targeting. The composition and method are also useful for inhibiting the proliferation of cancer cells by halting the transcription process.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: November 20, 2001
    Assignee: Promelas Research Corporation
    Inventors: Timothy N. Tillman, Daryl L. Thompson, Gordon J. Rafool
  • Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
    Patent number: 6090602
    Abstract: An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiretroviral to the infected system, wherein the reverse transcription process is inhibited via steric hindrance, halting the viral RNA replication. Delivery may be accomplished by conventional methods, such as via oral dosing or injection. Additional delivery methods are also contemplated, including packaging in liposomes and protein targeting. The composition and method are also useful for inhibiting the proliferation of cancer cells by halting the transcription process.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: July 18, 2000
    Assignee: Promelas Research Corporation
    Inventors: Timothy N. Tillman, Daryl L. Thompson, Gordon J. Rafool