Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is already being administered quinidine or is suffering from a disease or disorder treatable by quinidine.

Abstract: Provided is a method of treating a neurological or psychiatric disease or disorder in a patient in need thereof, comprising: administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to the patient in need thereof, the patient also being administered a strong cytochrome P450 2D6 (CYP2D6) inhibitor.

Abstract: Provided is a method of treating a neurological or psychiatric disease or disorder in a patient in need thereof, comprising: administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to the patient in need thereof wherein the patient is a CYP2D6 poor metabolizer.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is already being administered quinidine or is suffering from a disease or disorder treatable by quinidine.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is also being administered a CYP2C8 substrate, such as repaglinide.

Abstract: A fairing attachable beneath a lower, outer longitudinal edge of a trailer. The fairing has longitudinally extending forward and rearward sections. The rearward section can be moved longitudinally to adjustably locate its rearward edge in a selected position forward of the trailer's wheel assembly. Such adjustable positioning occurs automatically if the rearward section is coupled to and longitudinally movable with the support frame for the trailer's wheel assembly, thus maintaining the rearward edge of the fairing in the selected position whenever the trailer's wheel assembly is longitudinally adjusted relative to the trailer. A hinge mechanism coupled between the trailer and the fairing allows pivotal displacement of each fairing section between lowered and raised positions. The lowered position is for long distance haulage of the trailer in order to achieve fuel economy. The raised position is for situations in which the trailer must be manoeuvred over ramps, uneven terrain, etc.

Abstract: A fairing for use on a trailer. The trailer has a first member of the first edge that is hingedly attached to the trailer of the first edge. A second member has a first edge also hingedly attached to the trailer at that edge. A third member has a first edge hingedly attached to the trailer and arranged adjacent to the second member. The third member is telescopically receivable within the second member. The fairing is arranged along the lower edge of a trailer, adjacent the wheel.