Patents by Inventor Gordon R. McInroy

Gordon R. McInroy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods related to nucleic acid synthesis
    Patent number: 11807887
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 7, 2023
    Assignee: Nuclera, Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • Compositions and methods related to non-templated enzymatic nucleic acid synthesis
    Patent number: 11505815
    Abstract: The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: November 22, 2022
    Assignee: Nuclera Nucleics, Ltd.
    Inventors: Michael C. Chen, Gordon R. McInroy
  • Compositions and Methods Related to Nucleic Acid Synthesis
    Publication number: 20220112534
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 14, 2022
    Applicant: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • Compositions and methods related to nucleic acid synthesis
    Patent number: 11236377
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: February 1, 2022
    Assignee: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID PREPARATION
    Publication number: 20210261998
    Abstract: The invention relates to a method of nucleic acid synthesis comprising the use of 3?-O-azidomethyl blocked nucleotide triphosphates which comprises the step of adding a capping group to any uncleaved 3?-O-azidomethyl groups and to the use of kits comprising said capping groups in a method of nucleic acid synthesis. The invention also relates to capped nucleotide triphosphates and 3?-O-azidomethyl capping groups.
    Type: Application
    Filed: February 16, 2021
    Publication date: August 26, 2021
    Applicant: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • Compositions and Methods Related to Nucleic Acid Synthesis
    Publication number: 20200332333
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 22, 2020
    Applicant: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • Compositions and methods related to nucleic acid synthesis
    Patent number: 10745727
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: August 18, 2020
    Assignee: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • Novel Use
    Publication number: 20190144905
    Abstract: The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 16, 2019
    Applicant: Nuclera Nucleics Ltd.
    Inventors: Michael C. Chen, Gordon R. McInroy
  • Azidomethyl Ether Deprotection Method
    Publication number: 20180201968
    Abstract: The invention relates to a method of converting an azidomethyl ether substituent to a free hydroxyl group. The invention also relates to methods of nucleic acid synthesis and sequencing comprising the use of nucleotide triphosphates having a 3?-O-azidomethyl substituent, to kits comprising nucleotide triphosphates having a 3?-O-azidomethyl substituent and photoactivatable transition metal complex and to the use of said kits in methods of nucleic acid synthesis and sequencing.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 19, 2018
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy
  • NOVEL USE
    Publication number: 20180023108
    Abstract: The invention relates to the use of specific terminal deoxynucleotidyl transferase (TdT) enzymes in a method of nucleic acid synthesis, to methods of synthesizing nucleic acids, and to the use of kits comprising said enzymes in a method of nucleic acid synthesis. The invention also relates to the use of terminal deoxynucleotidyl transferases and 3?-blocked nucleotide triphosphates in a method of template independent nucleic acid synthesis.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 25, 2018
    Inventors: Michael C. CHEN, Radu A. LAZAR, Jiahao HUANG, Gordon R. MCINROY
  • A Process for the Preparation of Nucleic Acid by Means of 3'-O-Azidomethyl Nucleotide Triphosphate
    Publication number: 20180016609
    Abstract: The invention relates to a method of nucleic acid synthesis comprising the use of 3?-O-azidomethyl blocked nucleotide triphosphates which comprises the step of adding a capping group to any uncleaved 3?-O-azidomethyl groups and to the use of kits comprising said capping groups in a method of nucleic acid synthesis. The invention also relates to capped nucleotide triphosphates and 3?-O-azidomethyl capping groups.
    Type: Application
    Filed: March 3, 2016
    Publication date: January 18, 2018
    Inventors: Michael C. Chen, Radu A. Lazar, Jiahao Huang, Gordon R. McInroy