Patents by Inventor Gordon Rewcastle

Gordon Rewcastle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
    Patent number: 10544215
    Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: January 28, 2020
    Assignee: Genentech, Inc.
    Inventors: John A. Flygare, Thomas H. Pillow, Brian Safina, Vishal Verma, BinQing Wei, William Denny, Anna Giddens, Ho Lee, Guo-Liang Lu, Christian Miller, Gordon Rewcastle, Moana Tercel, Muriel Bonnet
  • 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
    Patent number: 10442836
    Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: October 15, 2019
    Assignee: Genentech, Inc.
    Inventors: John Flygare, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, William Denny, Anna Giddens, Ho Lee, Guo-Liang Lu, Christian Miller, Gordon Rewcastle, Moana Tercel, Muriel Bonnet
  • 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
    Publication number: 20160354485
    Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
    Type: Application
    Filed: June 14, 2016
    Publication date: December 8, 2016
    Applicant: Genentech, Inc.
    Inventors: John A. Flygare, Thomas H. Pillow, Brian Safina, Vishal Verma, BinQing Wei, William Denny, Anna Giddens, Ho Lee, Guo-Liang Lu, Christian Miller, Gordon Rewcastle, Moana Tercel, Muriel Bonnet
  • 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
    Publication number: 20150165063
    Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
    Type: Application
    Filed: June 16, 2014
    Publication date: June 18, 2015
    Inventors: John Flygare, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, William Denny, Anna Giddens, Ho Lee, Guo-Liang Lu, Christian Miller, Gordon Rewcastle, Moana Tercel, Muriel Bonnet
  • PTERIDINONES AS KINASE INHIBITORS
    Publication number: 20070049600
    Abstract: Disclosed are compounds of the formula wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.
    Type: Application
    Filed: October 27, 2006
    Publication date: March 1, 2007
    Inventors: William Denny, Gordon Rewcastle, Ellen Dobrusin, James Kramer, Dennis McNamara, Howard Daniel Showalter, Peter Toogood
  • N-(4 substituted phenyl)-anthranilic acid hydroxamate esters
    Publication number: 20050137263
    Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: February 4, 2005
    Publication date: June 23, 2005
    Inventors: Gordon Rewcastle, Julie Spicer, Stephen Barrett, Michael Kaufman, Jared Milbank, Haile Tecle
  • Imidazopyridines and triazolopyridines
    Publication number: 20050049276
    Abstract: The present invention relates to imidazopyridine and triazolopyridine derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: July 20, 2004
    Publication date: March 3, 2005
    Inventors: Michael Kaufman, Mark Plummer, Gordon Rewcastle
  • 5-Substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives
    Publication number: 20050026964
    Abstract: The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: June 24, 2004
    Publication date: February 3, 2005
    Inventors: Shannon Black, Michael Kaufman, Daniel Ortwine, Mark Plummer, John Quin, Gordon Rewcastle, Aurash Shahripour, Julie Spicer, Christopher Whitehead