Patents by Inventor Gordon W. Gribble

Gordon W. Gribble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
    Patent number: 8981144
    Abstract: The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid, sumaresinolic acid or hederagenin.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: March 17, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu
  • Compositions and methods for treating cancer
    Patent number: 8975274
    Abstract: The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: March 10, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Justin M. Lopchuk
  • TRITERPENOIDS AND COMPOSITIONS CONTAINING THE SAME
    Publication number: 20150011627
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Application
    Filed: September 25, 2014
    Publication date: January 8, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • Triterpenoids and compositions containing the same
    Patent number: 8921419
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: December 30, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
    Patent number: 8921340
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: December 30, 2014
    Assignees: Trustees of Dartmouth College, Rutgers, The State University of New Jersey, The United States of America, as represented by the Secretary Department of Health and Human Services
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
  • METHODS FOR USING SYNTHETIC TRITERPENOIDS IN THE TREATMENT OF BONE OR CARTILAGE DISEASES OR CONDITIONS
    Publication number: 20140377235
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
  • METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS
    Publication number: 20140328809
    Abstract: The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Gordon W. Gribble, Damian Medici, Pamela Gehron Robey, Karen T. Liby, Michael B. Sporn, Nanjoo Suh
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20140275618
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Application
    Filed: October 21, 2013
    Publication date: September 18, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Gordon W. GRIBBLE, Tadashi HONDA, Michael B. SPORN, Nanjoo SUH
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20140228392
    Abstract: The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound.
    Type: Application
    Filed: September 18, 2012
    Publication date: August 14, 2014
    Inventors: Gordon W. Gribble, Justin M. Lopchuk
  • Betulinic acid derivatives and methods of use thereof
    Patent number: 8778990
    Abstract: This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: July 15, 2014
    Assignees: Trustees of Dartmouth College, Reata Pharmaceuticals, Inc.
    Inventors: Tadashi Honda, Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Robert M. Kral, Jr., Melean Visnick
  • Bis-carbazole DNA intercalating agents for antitumor therapy
    Patent number: 8765781
    Abstract: The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an antitumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: July 1, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Dmity A. Androsov
  • Therapeutic compounds and methods of use
    Patent number: 8586775
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: November 19, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Triterpenoids and Compositions Containing the Same
    Publication number: 20130303607
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Application
    Filed: May 8, 2012
    Publication date: November 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • METHOD FOR SYNTHESIZING 2-CYANO-3,12-DIOXOOLEAN-1, 9(11)-DIEN-28-OIC ACID METHYL ESTER AND DERIVATIVES THEREOF
    Publication number: 20130303797
    Abstract: The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid, sumaresinolic acid or hederagenin.
    Type: Application
    Filed: May 8, 2012
    Publication date: November 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20130237721
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Application
    Filed: August 24, 2011
    Publication date: September 12, 2013
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Compositions and methods for treating cancer
    Patent number: 8530496
    Abstract: The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the antitumor compound.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: September 10, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Justin M. Lopchuk
  • Compositions and methods for treating cancer
    Patent number: 8518965
    Abstract: The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial cell proliferation and preventing or treating colon cancers and gliomas.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: August 27, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Dmitry A. Androsov
  • Synthetic triterpenoids and methods of use in the treatment of disease
    Patent number: 8455544
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 4, 2013
    Assignees: Reata Pharmaecuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
    Patent number: 8299046
    Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: October 30, 2012
    Assignees: Trustees of Dartmouth College, Osteoscreen, Inc., The Regents of the Universtiy of California
    Inventors: Michael B. Sporn, Karen T. Liby, Tadashi Honda, Gregory Mundy, Ross Garrett, Hari Reddi, Gordon W. Gribble, Takahiro Niikura
  • Synthetic Triterpenoids and Methods of Use in the Treatment of Disease
    Publication number: 20120220652
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Application
    Filed: January 26, 2012
    Publication date: August 30, 2012
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer